AI Article Synopsis
- A 59-year-old man was diagnosed with gallbladder cancer after surgery for gallstones and cholecystitis, finding moderately differentiated adenocarcinoma in the gallbladder.
- Sixteen days post-surgery, he presented with jaundice, and imaging revealed unresectable liver and lymph node metastases.
- After chemotherapy with gemcitabine and cisplatin led to a complete response, he underwent additional surgery with no residual cancer found, and remains alive with no signs of recurrence over a year later.
Article Abstract
A 59-year-old man was diagnosed with cholecystolithiasis and cholecystitis and underwent cholecystectomy. The pathological findings were moderately differentiated adenocarcinoma(pT2)in the gallbladder fundus. Sixteen days after surgery, he visited our hospital due to jaundice. Abdominal enhanced CT and EOB-MRI revealed multiple liver metastases and lymph node metastases in the hepatoduodenal ligament that we deemed to be unresectable. A metallic stent was inserted for bile duct obstruction, and he underwent chemotherapy with gemcitabine plus cisplatin(GC). After 12 courses of GC, the metastatic lesions disappeared, and the patient showed complete response. FDG-PET/CT showed FDG uptake in the hepatoduodenal ligament and we subsequently decided to perform surgery. He underwent resection of the extrahepatic bile duct and regional lymphadenectomy. The pathological findings revealed no residual carcinomas in the bile duct or lymph nodes. We are continuing chemotherapy at present, and the patient is alive with no signs of recurrence at 1 year and 3 months following the diagnosis of multiple liver metastases.
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