The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249113 | PMC |
| http://dx.doi.org/10.3390/molecules25092160 | DOI Listing |
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