AI Article Synopsis
- - The study analyzed macular pigment optical density (MPOD) and photoreceptor outer segment (PROS) length to identify early biomarkers for age-related macular degeneration (AMD) in 30 high-risk eyes compared to 30 healthy control eyes.
- - Results showed that AMD fellow eyes had significantly lower MPOD and shorter PROS length than the control eyes, suggesting that these metrics might indicate a high risk of developing AMD.
- - A notable percentage of AMD fellow eyes met the criteria for low MPOD and PROS length, indicating that these combined measures could be potential biomarkers for early screening of AMD, though further research is needed to confirm these findings.
Article Abstract
To explore predisease biomarkers, which may help screen for the risk of age-related macular degeneration (AMD) at very early stages, macular pigment optical density (MPOD) and photoreceptor outer segment (PROS) length were analyzed. Thirty late AMD fellow eyes, which are at high risk and represent the predisease condition of AMD, were evaluated and compared with 30 age-matched control eyes without retinal diseases; there was no early AMD involvement in the AMD fellow eyes. MPOD was measured using MPS2 (M.E. Technica Co. Ltd., Tokyo, Japan), and PROS length was measured based on optical coherence tomography images. MPOD levels and PROS length in the AMD fellow eyes were significantly lower and shorter, respectively, than in control eyes. MPOD and PROS length were positively correlated in control eyes (R = 0.386; = 0.035) but not in AMD fellow eyes. Twenty (67%) AMD fellow eyes met the criteria of MPOD < 0.65 and/or PROS length < 35 μm, while only five (17%) control eyes did. After adjusting for age and sex, AMD fellow eyes more frequently satisfied the definition ( < 0.001; 95% confidence interval, 3.50-60.4; odds ratio, 14.6). The combination of MPOD and PROS length may be a useful biomarker for screening predisease AMD patients, although further studies are required in this regard.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290696 | PMC |
| http://dx.doi.org/10.3390/jcm9051347 | DOI Listing |
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