The first total synthesis of echinomycin () was accomplished by featuring the late-stage construction of the thioacetal moiety via Pummerer rearrangement and simultaneous cyclization, as well as two-directional elongation of the peptide chains to construct a 2-symmetrical bicyclic octadecadepsipeptide bridged with a sulfide linkage. This strategy can be applicable to a variety of echinomycin analogues.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.0c01268 | DOI Listing |
Publication Analysis
Top Keywords
total synthesis
8
synthesis echinomycin
8
echinomycin analogues
8
analogues total
4
echinomycin accomplished
4
accomplished featuring
4
featuring late-stage
4
late-stage construction
4
construction thioacetal
4
thioacetal moiety
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!