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Segmentation aware probabilistic phenotyping of single-cell spatial protein expression data.
Nat Commun
January 2025
Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Spatial protein expression technologies can map cellular content and organization by simultaneously quantifying the expression of >40 proteins at subcellular resolution within intact tissue sections and cell lines. However, necessary image segmentation to single cells is challenging and error prone, easily confounding the interpretation of cellular phenotypes and cell clusters. To address these limitations, we present STARLING, a probabilistic machine learning model designed to quantify cell populations from spatial protein expression data while accounting for segmentation errors.
View Article and Find Full Text PDFSuccessful pregnancy of an SMA type 3 sitter on Nusinersen therapy - a case report.
BMC Neurol
January 2025
Department of Neurology, Friedrich-Baur-Institute, Ludwig-Maximilians-University of Munich, Munich, Germany.
Background: Due to improved treatment options, more SMA patients reach childbearing age. Currently, limited data on pregnant SMA patients is available, especially in relation to disease-modifying therapies (DMT). This case report helps to elucidate new approaches for future guidelines in the management of pregnancy and SMA.
View Article and Find Full Text PDFRurality predisposes departure from gold-standard care, leading to delayed or accelerated access to surgery: insights from a scoping review.
Can J Surg
January 2025
From the Cumming School of Medicine, University of Calgary, Calgary, Alta. (Ebrahim, Sinha, Adedipe, Ahmad, Amyotte, Yang); the Canadian Global Surgery Trainees' Association affiliated with the International Student Surgical Network - InciSioN (Ebrahim, Sinha, Adedipe, Ahmad, Amyotte, Yang, Elsewify); the Faculty of Medicine and Health Sciences, Laval University, Québec City, Que. (Elsewify); the Division of Plastic and Reconstructive Surgery, University of Western Ontario, London, Ont. (Sachal); the Sections of Pediatric Surgery and Plastic Surgery, Department of Surgery, University of Calgary, Calgary, Alta. (Fraulin); the Departments of Clinical Neurosciences and Surgery, University of Calgary, Calgary, Alta. (Gabriel); the Department of Distributed Learning and Rural Initiatives, Cumming School of Medicine, University of Calgary, Calgary, Alta. (Perez, Johnston)
Background: Because tertiary centres are generally situated at urban sites, it is unclear whether patients in rural areas have the same access to surgical services that patients in urban areas do. We sought to map the North American evidence landscape of how rurality affects access to medically indicated surgeries and identify system-, patient-, and provider-level barriers that preclude urban-comparable care.
Methods: We carried out a systematic search adhering to PRISMA for Scoping Reviews methodology across PubMed, MEDLINE, Scopus, and Web of Science, encompassing literature from the last 26 years (January 2023).
Reliability of the OMERACT Giant cell arteritis Ultrasonography Score (OGUS): results of a patient-based exercise involving experts and non-experts in vascular ultrasonography.
RMD Open
January 2025
Rheumatology, Medical University of Graz, Graz, Austria.
Objective: To test the reliability of the Outcome Measures in Rheumatology Giant cell arteritis (GCA) Ultrasonography Score (OGUS) and other composite scores in a patient-based exercise involving experts and non-experts in vascular ultrasonography.
Methods: Six GCA patients were scanned twice (two rounds separated ≥3 hours) by 12 experts and 12 non-experts. Non-experts received 90 min of theoretical and 240 min of practical training between rounds 1 and 2.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Background: Disrupted balance between amyloidogenic and non-amyloidogenic pathways leads to cognitive decline in Alzheimer's disease (AD). Evidence suggests vitamin A (VA) supplementation favors the non-amyloidogenic pathway through upregulation of α-secretase. Originally used to map embryonic retinoic acid (RA) signaling, RARE-LacZ mice possess multiple LacZ genes controlled by retinoic acid response elements (RAREs).
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