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Circulatory CCL2 distinguishes Duchenne muscular dystrophy dogs.
Dis Model Mech
March 2025
Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO 65212, USA.
To establish a minimally invasive approach to studying body-wide muscle inflammation in the canine Duchenne muscular dystrophy (DMD) model, we evaluated 13 cytokines/chemokines in frozen sera from 90 affected (239 sera) and 73 normal (189 sera) dogs (0.00 to 45.2 months of age).
View Article and Find Full Text PDFBrain Morphometrics Correlations With Age Among 350 Participants Imaged With Both 3T and 7T MRI: 7T Improves Statistical Power and Reduces Required Sample Size.
Hum Brain Mapp
March 2025
Departments of Bioengineering, Psychiatry, and Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Magnetic resonance imaging (MRI) at 7T has a superior signal-to-noise ratio to 3T but also presents higher signal inhomogeneities and geometric distortions. A key knowledge gap is to robustly investigate the sensitivity and accuracy of 3T and 7T MRI in assessing brain morphometrics. This study aims to (a) aggregate a large number of paired 3T and 7T scans to evaluate their differences in quantitative brain morphological assessment using a widely available brain segmentation tool, FreeSurfer, as well as to (b) examine the impact of normalization methods for subject variability and smaller sample sizes on data analysis.
View Article and Find Full Text PDFHuman BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage.
Nat Methods
March 2025
Department of Intelligent Systems Engineering, Luddy School of Informatics, Computing, and Engineering, Indiana University, Bloomington, IN, USA.
The Human BioMolecular Atlas Program (HuBMAP) aims to construct a 3D Human Reference Atlas (HRA) of the healthy adult body. Experts from 20+ consortia collaborate to develop a Common Coordinate Framework (CCF), knowledge graphs and tools that describe the multiscale structure of the human body (from organs and tissues down to cells, genes and biomarkers) and to use the HRA to characterize changes that occur with aging, disease and other perturbations. HRA v.
View Article and Find Full Text PDFPlasma exchange and radiation resensitize immunotherapy-refractory melanoma: a phase I trial.
Nat Commun
March 2025
Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
Immune checkpoint inhibitors (ICI) are effective for advanced melanoma. However, most develop ICI resistance. Tumor-derived soluble PD-L1 (sPD-L1) and other immunosuppressive factors drive resistance.
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