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Prognostic Value of / Status for Overall Survival in First-Line Monoimmunotherapy and Chemoimmunotherapy Treated Patients With Nonsquamous NSCLC in the Netherlands: A Brief Report.
JTO Clin Res Rep
December 2024
Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Introduction: Programmed death-ligand 1 (PD-L1) is the main predictive biomarker used to identify patients with NSCLC who are eligible for treatment with immune checkpoint inhibitors. Despite its utility, the predictive capacity of PD-L1 is limited, necessitating the exploration of supplementary predictive biomarkers. In this report, we describe the prognostic value of / mutation status for overall survival (OS) in patients with NSCLC treated with first-line immunotherapy or combined chemoimmunotherapy.
View Article and Find Full Text PDFThe State of Radiology Research in Ethiopia: A Scoping Review.
Ethiop J Health Sci
October 2024
Department of Public Health, School of Public Health, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Background: Radiology is an essential component of modern medicine and a rapidly evolving research field. The nature and dynamic of radiology research in Ethiopia remained largely unexplored This bibliometric scoping review was done to explore the current state of radiology research in Ethiopia.
Methods: Literature search was conducted using PubMed, Scopus, Embase, Web of Science, and Google Scholar from inception to June 15, 2024.
Conservation of structural brain connectivity in people with multiple sclerosis.
Netw Neurosci
December 2024
Neuroradiology Group, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
Multiple sclerosis (MS) is a neurodegenerative disease that affects the central nervous system. Structures affected in MS include the corpus callosum, connecting the hemispheres. Studies have shown that in mammalian brains, structural connectivity is organized according to a conservation principle, an inverse relationship between intra- and interhemispheric connectivity.
View Article and Find Full Text PDFA spatially constrained independent component analysis jointly informed by structural and functional network connectivity.
Netw Neurosci
December 2024
Tri-institute Translational Research in Neuroimaging and Data Science (TReNDS Center), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
There are a growing number of neuroimaging studies motivating joint structural and functional brain connectivity. The brain connectivity of different modalities provides an insight into brain functional organization by leveraging complementary information, especially for brain disorders such as schizophrenia. In this paper, we propose a multimodal independent component analysis (ICA) model that utilizes information from both structural and functional brain connectivity guided by spatial maps to estimate intrinsic connectivity networks (ICNs).
View Article and Find Full Text PDFCoCoNest: A continuous structural connectivity-based nested family of parcellations of the human cerebral cortex.
Netw Neurosci
December 2024
Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Despite the widespread exploration and availability of parcellations for the functional connectome, parcellations designed for the structural connectome are comparatively limited. Current research suggests that there may be no single "correct" parcellation and that the human brain is intrinsically a multiresolution entity. In this work, we propose the Continuous Structural Connectivitity-based, Nested (CoCoNest) family of parcellations-a fully data-driven, multiresolution family of parcellations derived from structural connectome data.
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