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Congenital Syphilis Presenting with Prenatal Bowel Hyperechogenicity and Necrotizing. | LitMetric

Congenital Syphilis Presenting with Prenatal Bowel Hyperechogenicity and Necrotizing.

Sisli Etfal Hastan Tip Bul

Department of Pediatrics, Division of Neonatology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Published: March 2020

AI Article Synopsis

  • Congenital syphilis is caused by the transmission of the bacteria Treponema pallidum from mother to fetus, leading to severe health issues in newborns, with symptoms varying based on several factors like gestational age and maternal treatment.
  • Symptomatic newborns may experience a range of complications, including prematurity, low birth weight, intestinal issues, and blood disorders, as seen in a case of a premature baby with multiple health problems.
  • Despite treatment with penicillin improving some symptoms, the baby eventually developed perforated necrotizing enterocolitis, leading to a series of surgeries and ultimately death, suggesting a strong link between the congenital syphilis and the intestinal condition.

Article Abstract

Congenital syphilis is a severe disease that arises from the vertical transmission of Treponema pallidum. Clinical findings are related to the pregnancy stage, fetal gestational week, maternal treatment and fetal immunologic response. Prematurity, low birth weight, nonimmune hydrops fetalis, necrotizing enterecolitis, hepatomegaly, skin eruptions, thrombocytopenia, hemolytic anemia and fever can be detected in the symptomatic newborn. Postnatal respiratory insufficiency, hepatomegaly, anemia and thrombocytopenia were detected in a baby who was born at the 29 week of gestation, weighing 1.160 g and followed due to intestinal hyperechogenicity from the second trimester. Her and her mother's Venereal Disease Research Laboratory titers were positive, confirming test Treponema pallidum hemagglutination was reactive. After penicillin was administered for 10 days, anemia, and thrombocytopenia were regressed. In the 15 day of life, findings of perforated necrotising enterocolitis (NEC) suddenly appeared. The operation was performed due to NEC for three times but nonresponsive laboratory and clinical findings and died in the 54 day of life. We assumed that syphilis is the cause of both bowel hyperechogenicity and necrotising enterocolitis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192246PMC
http://dx.doi.org/10.14744/SEMB.2018.22605DOI Listing

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