An extensive phytochemical study of a foliose lichen from Indonesia, , resulted in the successful isolation of 13 phenol and depside derivatives (-) including the previously unreported depsides 3'-hydroxyl-5'-pentylphenyl 2,4-dihydroxyl-6-methylbenzoate (), 3'-hydroxyl-5'-propylphenyl 2,4-dihydroxyl-6-methylbenzoate () and 3'-hydroxyl-5'-methylphenyl 2-hydroxyl-4-methoxyl-6-propylbenzoate (). The anti-infective activity of isolated compounds was evaluated against the gram-negative bacterium and the nematode . 2,4-Dihydroxyl-6-pentylbenzoate () and lecanoric acid () induced growth inhibition of with inhibition values of 49% and 100% at a concentration of 100 µM, respectively. The antibacterial activity might be due to their free carboxyl group. A phenolic group at C4 also contributed to the antimicrobial activity of the depsides as shown for compounds and , which caused 89% and 96% growth inhibition at 100 µM, respectively. Lecanoric acid () in addition possesses significant anthelmintic effects causing 80% mortality of at 100 µg/mL.
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