A new additive, methyl(phenyl)formamide (MPF), is introduced for the glycosylation of 2-azido-2-deoxyglucose building blocks. A linear α-(1,4)-glucosamine tetrasaccharide was assembled to prove the utility of MPF. Next, a hexasaccharide fragment of the exopolysaccharide Pel was assembled using a [2 + 2 + 2] strategy modulated by MPF. The used [galactosazide-α-(1,4)-glucosazide] disaccharide building blocks were synthesized using a 4,6--DTBS protected galactosyl azide donor.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754192 | PMC |
| http://dx.doi.org/10.1021/acs.joc.0c00703 | DOI Listing |
Publication Analysis
Top Keywords
building blocks
8
reagent controlled
4
controlled glycosylations
4
glycosylations assembly
4
assembly well-defined
4
well-defined pel
4
pel oligosaccharides
4
oligosaccharides additive
4
additive methylphenylformamide
4
methylphenylformamide mpf
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!