The article "Regulatory effect of lncRNA NKILA on autophagy induced by sepsis kidney injury, by Y.-M. Yang, Y.-H. Li, L.-L. Ding, Y. Fu, N. Li, published in Eur Rev Med Pharmacol Sci 2019; 23(18):8011-8017. DOI: 10.26355/eurrev_201909_19017. PMID: 31599426" has been withdrawn from the authors. The Publisher apologizes for any inconvenience this may cause.
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LncRNA NKILA attenuates the progression of osteoarthritis through the targeted inhibition of the NF-κB pathway.
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Department of Orthopaedics, The First Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, China. Electronic address:
Background: Interleukin-1β (IL-1β) plays a crucial role in cartilage degeneration by inducing inflammatory cascades in chondrocytes, impairing their normal biological functions. Long non-coding RNA NKILA (lncRNA NKILA) has been implicated in osteoarthritis (OA), but its specific molecular mechanisms remain unclear. This study aims to elucidate the function and molecular regulatory mechanism of lncRNA NKILA in articular chondrocytes under IL-1β stimulation.
View Article and Find Full Text PDFEffect of Priming With Toll-Like Receptor 3 Agonist on Expression of Long Noncoding RNAs in Human Wharton Jelly Mesenchymal Stem Cells.
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>From the Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Article Synopsis
- Mesenchymal stem cells from human Wharton jelly are being studied for their anti-inflammatory and immunosuppressive functions, which can be influenced by inflammatory conditions.
- The study involved isolating these stem cells and exposing them to polyinosinic-polycytidylic acid to see how it affected the expression of specific long noncoding RNAs.
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A methylation-related lncRNA-based prediction model in lung adenocarcinomas.
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Background: The collaboration between methylation and the lung adenocarcinoma (LUAD) occurrence and development is closes. Long noncoding RNA (lncRNA), as a regulatory factor of various biological functions, can be used for cancer diagnosis. Our study aimed to construct a robust methylation-related lncRNA signature of LUAD.
View Article and Find Full Text PDFAssociation between NKILA and some apoptotic gene expression in atherosclerosis.
PeerJ
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Department of Medical Biology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey.
Oxidized light-density lipoprotein (ox-LDL) causes endothelial dysfunction, which is an important determinant of atherogenesis, and subsequently leads to apoptosis. Atherosclerosis is one of the most significant cardiovascular diseases (CVDs) threatening human health and causes death worldwide. Recently, long noncoding RNAs (lncRNAs) have been suggested to involved in vascular biology.
View Article and Find Full Text PDFProto-oncogene c-Myb potentiates cisplatin resistance of ovarian cancer cells by downregulating lncRNA NKILA and modulating cancer stemness and LIN28A-let7 axis.
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Ovarian cancer is a major gynecological cancer that has poor prognosis associated mainly to its late diagnosis. Cisplatin is an FDA approved ovarian cancer therapy and even though the therapy is initially promising, the patients mostly progress to resistance against cisplatin. The underlying mechanisms are complex and not very clearly understood.
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