Overexpression of the PbrlaeA gene of the fungus HDN-12-143 resulted in the isolation of four compounds including fumigatin chlorohydrin (), whose configuration has not been reported before, and one new compound iso-fumigatin chlorohydrin (). All structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic data, C NMR calculations, and ECD calculations. Compounds and exhibited cytotoxic activity against HL-60 with IC of 18.63 and 24.83 μM.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186497 | PMC |
| http://dx.doi.org/10.3389/fchem.2020.00270 | DOI Listing |
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