This is the sixteenth chapter of the guideline "Calculated initial parenteral treatment of bacterial infections in adults - update 2018" in the 2 updated version. The German guideline by the Paul-Ehrlich-Gesellschaft für Chemotherapie e.V. (PEG) has been translated to address an international audience. Infections due to multiresistant Gram-negative rods are challenging. In this chapter recommendations for targeted therapy for infections caused by ESBL-producing Enterobacteriaceae, carbapenemase-producing Enterobacteriaceae and carbapenem-resistant are given, based on the limited available evidence.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186793 | PMC |
| http://dx.doi.org/10.3205/id000048 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Charge Regulation-Enhanced Type I Photosensitizer-Loaded Hydrogel Dressing for Hypoxic Bacterial Inhibition and Biofilm Elimination.
ACS Nano
January 2025
State Key Laboratory of Fine Chemicals, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518055, China.
Biofilm-induced chronic bacterial infections represent a significant challenge in modern medicine due to their resistance to conventional antibiotic treatments. Although photodynamic therapy (PDT) has emerged as a promising antibiotic-free antibacterial strategy, the hypoxic condition within biofilms and the lack of an effective local drug delivery system have limited the clinical effectiveness of photosensitizer (PS) agents. Herein, we propose a type of charge regulation-enhanced type I PS-loaded hydrogel dressing for treating biofilm infection.
View Article and Find Full Text PDFOvercoming (X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations.
Front Microbiol
December 2024
Guangdong Laboratory for Lingnan Modern Agriculture, National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Introduction: The emergence of the wide variety of novel tigecycline resistance (X) variants, including (X3), (X4), (X5), and (X6), has raised a serious threat to global public health and posed a significant challenge to the clinical treatment of multidrug-resistant bacterial infections.
Methods: In this study, we evaluated the synergism of tigecycline combining with other antibiotics as a means of overcoming the (X)-mediated resistance in spp. Antibiotic synergistic efficacy was evaluated through chequerboard experiments, time-kill assays and dose-response curves.
A cross-sectional survey of farmer reported prevalence and farm management practices associated with neonatal infectious arthritis ("joint ill") in lambs, on UK sheep farms.
Front Vet Sci
December 2024
Department of Livestock and One Health, Institute of Infection, Veterinary and Ecologica Science, University of Liverpool, Neston, United Kingdom.
Introduction: Neonatal infectious arthritis (NIA) is a bacterial disease of lambs in the first month of life. NIA is associated with poor animal welfare, economic losses, and prophylactic antibiotic use. Farmers report problems with NIA despite following current guidance on prevention.
View Article and Find Full Text PDFSurvey of the approach to the diagnosis and management of bacterial pneumonia in adult horses by equine veterinarians.
Front Vet Sci
December 2024
Consultant, Athens, GA, United States.
Bacterial pneumonia is a common disease in adult horses, but there are no guidelines for practitioners regarding risk factors, diagnosis, and management of the disease. The objectives of this study were to describe how a group of equine veterinarians diagnose and treat bacterial pneumonia in adult horses. A 22-question survey was distributed via multiple platforms to equine veterinarians asking questions regarding the frequency with which they identified specific clinical findings and used certain diagnostic modalities, and the approach to antimicrobial and adjunct therapy.
View Article and Find Full Text PDFSevere Delayed-Onset Meningitis Developed One Year After a Basilar Skull Fracture Without a Cerebrospinal Fluid Leak: A Case Report.
Cureus
December 2024
Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, JPN.
Traumatic cerebrospinal fluid (CSF) leakage from skull base fractures increases the risk of bacterial meningitis, which is associated with a high mortality rate in adults, and commonly results in severe neurological outcomes. While most cases of CSF leakage occur within three months post-injury and generally resolve spontaneously, delayed-onset meningitis remains a challenging complication. Herein, we report a rare case of severe bacterial meningitis with an intraventricular abscess one year following a frontal skull base fracture, despite no CSF leak.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!