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The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment: Discriminative Accuracy and Neural Correlates. | LitMetric

AI Article Synopsis

  • - The study investigates how episodic memory is affected in early-stage Parkinson's disease (PD) patients without dementia, comparing them to healthy controls and categorizing them into normal cognition and mild cognitive impairment groups using established criteria.
  • - Findings show that patients with mild cognitive impairment (PD-MCI) perform significantly worse on memory tasks compared to those with normal cognition (PD-NC) and healthy controls, with the best distinction between groups occurring at delayed total recall scores.
  • - Structural brain analyses reveal that poor memory performance in PD-MCI is linked to reduced gray matter volume and increased mean diffusivity in critical brain regions, highlighting encoding and retrieval deficits as common traits associated with brain damage in these patients.

Article Abstract

Memory alterations are common in Parkinson's disease (PD) patients but the mechanisms involved in these deficits remain poorly understood. The study aims to explore the profile of episodic memory deficits in non-demented early PD patients. We obtained neurological, cognitive and behavioral data from 114 PD patients and 41 healthy controls (HC). PD participants were grouped as normal cognition (PD-NC) and mild cognitive impairment (PD-MCI) according to the Level II criteria of the Movement Disorders Society Task Force (MDS-TF). We evaluate the performance amongst groups on an episodic memory task using the Free and Cued Selective Reminding Test (FCSRT). Additionally, gray matter volume (GMV) voxel based morphometry, and mean diffusivity (MD) analyses were conducted in a subset of patients to explore the structural brain correlates of FCSRT performance. Performance on all subscores of the FCSRT was significantly worse in PD-MCI than in PD-NC and HC. Delayed total recall (DTR) subscore was the best at differentiating PD-NC from PD-MCI. Using crosstabulation, DTR allowed identification of PD-MCI patients with an accuracy of 80%. Delayed free and cued recall was associated with decreased GMV and increased MD in multiple fronto-temporal and parietal areas. Encoding and retrieval deficits are a main characteristic of PD-MCI and are associated with structural damage in temporal, parietal and prefrontal areas.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186438PMC
http://dx.doi.org/10.3389/fneur.2020.00240DOI Listing

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