Purpose: To assess the pain intensity of two intracameral anesthetic solutions in patients undergoing cataract surgery and evaluate the factors influencing the patients' postoperative activities.
Methods: Sixty-two patients undergoing cataract surgery were randomized to receive the study drug - a manufactured solution of 0.02% tropicamide/0.31% phenylephrine/1% lidocaine (Mydrane) or a traditional anesthetic formulation - solution of 1% lidocaine/0.025% adrenaline as an intraocular anesthetic. The pain intensity was assessed by Visual Analog Scale for Pain (VAS Pain) and Brief Pain Inventory-short form (BPI) on the next day after the surgery.
Results: The mean pain score measured preoperatively with VAS Pain was 0.34 in Mydrane group and 0.09 in the reference group ( = 0.51). There were no statistically significant differences between the two anesthetic methods with respect to pain intensity during the surgery ( = 0.94) and the influence of pain during the last 24 h on activity ( = 0.79), mood ( = 0.31), social contacts ( = 0.29), sleep ( = 0.5) and the joy of life ( = 0.39). Additionally, there was no statistically significant influence of age, sex, lateralization, co-existing ophthalmological diseases ( = 0.98) and post-operative complications ( = 0.4) on the experienced pain measured during the surgery and in the last 24 h.
Conclusions: New commercially available intraocular anesthetic solution (Mydrane™) seems to be as effective as off-label traditional anesthetic formulation, in reducing the pain experienced during cataract surgery under topical anesthesia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176993 | PMC |
| http://dx.doi.org/10.3389/fphar.2020.00440 | DOI Listing |
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