Pharmacogenomics
Department of Biomedical Science, Section of Neuroscience & Clinical Pharmacology, University of Cagliari, Monserrato, Cagliari, 09042, Italy.
Published: June 2020
To assess the role of lithium treatment in the relationship between bipolar disorder (BD) and leukocyte telomere length (LTL). We compared LTL between 131 patients with BD, with or without a history of lithium treatment, and 336 controls. We tested the association between genetically determined LTL and BD in two large genome-wide association datasets. Patients with BD with a history lithium treatment showed longer LTL compared with never-treated patients (p = 0.015), and similar LTL compared with controls. Patients never treated with lithium showed shorter LTL compared with controls (p = 0.029). Mendelian randomization analysis showed no association between BD and genetically determined LTL. Our data support previous findings showing that long-term lithium treatment might protect against telomere shortening.
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http://dx.doi.org/10.2217/pgs-2020-0028 | DOI Listing |
Adv Sci (Weinh)
January 2025
Department of Prosthodontics, Peking University School and Hospital of Stomatology, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, China.
Zinc (Zn) and its alloys are promising biomaterials for orthopedic applications due to their degradability and mechanical properties. Zn plays a crucial role in bone formation, but excessive early release may cause cytotoxicity and inhibit osseointegration. To solve this, we developed a near-infrared (NIR) light-controlled polycaprolactone/copper-sulfur (PCL/CuS) coating that slows degradation and enhances osseointegration of Zn alloys.
View Article and Find Full Text PDFRSC Adv
January 2025
Department of Chemical and Materials Engineering, School of Engineering and Digital Sciences, Nazarbayev University Astana Kazakhstan
Sodium-ion batteries (SIBs) offer several advantages over traditional lithium-ion batteries, including a more uniform sodium distribution, lower-cost materials, and safer transportation options. A promising development in SIBs is the use of hard carbons as anode materials due to their low insertion voltage and larger interlayer spacing, which improve sodium-ion insertion. Traditionally, hard carbons are made from costly carbon sources, but recent advancements have focussed on using abundant bio-waste, like coffee grounds.
View Article and Find Full Text PDFJ Dent
January 2025
DDS, MS, PhD, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Brazil. Electronic address:
Objective: To evaluate the influence of different cleaning methods, surface treatments, and aging on the repair bond strength to a CAD/CAM glass-ceramic.
Materials And Methods: Forty-eight lithium disilicate CAD/CAM ceramic blocks were fabricated, sintered, and embedded in acrylic resin. After contamination with human saliva, they were divided according to the factors "Cleaning method" (Control-water/air spray, Air-particle abrasion with AlO, Ivoclean cleaning paste), "Surface treatment" (5% Hydrofluoric acid-HF + Silane, Monobond Etch & Prime-MEP), and "Aging" (thermocycling, no thermocycling).
Dalton Trans
January 2025
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.
Silicon-based anode materials experience significant volume changes and low conductivity during the lithiation process, which severely hinders their successful application in lithium-ion batteries. Reducing the size of silicon particles and effectively combining them with carbon-based materials are considered the main strategies to enhance the lithium-ion storage performance of silicon-based anodes. In this study, we employed a "bottom-up" strategy to synthesize Si@C anode materials by cross-linking octa-aminopropyl polyhedral oligomeric silsesquioxane (NH-POSS) with terephthalaldehyde and subsequent high-temperature treatment and low-temperature liquid reduction.
View Article and Find Full Text PDFSci Total Environ
January 2025
School of Environmental Science and Engineering, Shanghai Jiao Tong University, 200240, China.
The recycling of spent lithium-ion batteries has become a common concern of the whole society, with a large number of studies on recycling management and recycling technology, but there is relatively little study on the pollution release during the recycling process. Pollution will restrict the healthy development of the recycling industry, which makes relevant research very significant. This paper monitored and analyzed the battery recycling pretreatment process in a formal factory, and studied the pollution characteristics of particulate matter, heavy metals, and microplastics under different treatment stages.
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