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File: /var/www/html/application/controllers/Detail.php
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Mn(II)-Based MRI Contrast Agent Candidate for Vascular Imaging. | LitMetric
Toxicity concerns related to Gd(III)-based magnetic resonance imaging (MRI) agents prompted an intensive research toward their replacement by complexes of essential metal ions, like Mn(II). Here, we report a macrocyclic chelate, [Mn(PC2A-BP)], which possesses high thermodynamic stability (log = 14.86 and pMn=8.35) and kinetic inertness ( = 286.2 h) as well as as remarkable relaxivity ( = 23.5 mM s, 0.49 T, 37 °C) in the presence of human serum albumin, allowing a significant MRI signal intensity increase in the vasculature even at low dose (25 μmol/kg) of the complex.
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