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Introduction: Chagas disease, caused by the protozoan parasiteTrypanosoma cruzi, has no effective treatment available. On the other hand, microalgae are aquatic organisms that constitute an interesting reservoir of biologically active metabolites. Moreover, some species of green and red algae present anti-protozoan activity. Our aim was to study the antiparasitic effects of aqueous, methanolic and ethanolic extracts from different microalgae.
Methods And Results: Our results show that the methanolic extracts of S. obliquus and T. suecica as well as the ethanolic extracts of C. reinhardtii and T. suecica present trypanocidal activity on the infective extracellular trypomastigotes and intracellular amastigotes. In addition, the ethanolic extract of C. reinhardtii potentiates the activity of the conventional antichagasic drug nifurtimox. In order to identify some potential compounds with trypanocidal activity, we performed a phytochemical screening analyzing the presence of phenolic compounds, pigments and terpenoids.
Conclusion: The different microalgae extracts, particularly the ethanolic extract ofC. reinhardtii, are promising potential candidates for the development of future natural antichagasic drugs.
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http://dx.doi.org/10.1016/j.biopha.2020.110178 | DOI Listing |
Curr Microbiol
December 2024
B.S.Abdur Rahman Crescent Institute of Science & Technology, Chennai, Tamil Nadu, 600048, India.
Lichen-associated endophytic Actinobacteria, particularly Streptomyces species, are recognized for their production of bioactive secondary metabolites with significant pharmaceutical potential. With the escalating prevalence of diseases, Streptomyces species are being investigated for its natural source of antimicrobial compounds for new antibiotics. This study focuses on the bioactive properties of secondary metabolites from lichen-associated endophytic Actinobacteria, focusing on Streptomyces glaucescens NTSB-37 isolated form lichen, Parmotrema perlatum (Huds.
View Article and Find Full Text PDF3 Biotech
January 2025
Plant Cell Biotechnology (PCBT) Department, Central Food Technological Research Institute (CFTRI), Mysuru, 570 020 India.
Unlabelled: The present study evaluated the effects of 5-methyltetrahydrofolate (5-MTHF) and aqueous extract on diabetes. An in silico docking study with select bioactive compounds showed strong binding affinities of folates with glucose metabolism-related proteins. In vitro assay showed 5-MTHF's superior inhibitory activity on alpha-amylase compared to folic acid.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.
This study presents an innovative, eco-friendly approach to water treatment through the development of cryogels infused with bioactive Scenedesmus algal extract (ScAE) within a chitosan/poly(vinyl alcohol) (Cs/PVA) matrix. Scenedesmus sp., a green microalga known for its bioactive properties, was cultivated and processed to obtain extracts with coagulation potential.
View Article and Find Full Text PDFEnviron Monit Assess
December 2024
Department of Chemical Engineering, King Fahd University of Petroleum and Minerals, 31261, Dhahran, Saudi Arabia.
The sustainable treatment of petroleum-derived produced water (PW), a significant byproduct of oil and gas extraction, presents a persistent problem due to the presence of organic pollutants. This study examines the potential of the microalga Chlorella sorokiniana (C. sorokiniana) for the bioremediation of dissolved organic pollutants in PW.
View Article and Find Full Text PDFPlants (Basel)
November 2024
Department of Agricultural, Forest and Food Sciences (DISAFA), University of Turin, Largo Paolo Braccini 2, Grugliasco, 10095 Turin, Italy.
Using renewable biomass in agriculture, particularly microalgae as a biostimulant, offers economic and environmental sustainability benefits by reducing costs, improving nutrient cycling, and enhancing water use efficiency. Microalgae contain bioactive compounds that boost crop tolerance to environmental stresses, including salinity. Saline soils, characterized by elevated sodium chloride (NaCl) levels, negatively impact many crops, resulting in low productivity and high remediation costs.
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