AI Article Synopsis
- Hepatitis B virus (HBV) is a major global health concern, particularly transmitted from mother to child in Asian countries.
- Standard preventative measures have reduced transmission, but mothers with high viral loads still face higher risks.
- A study was conducted to evaluate the impact of using the drug telbivudine (LdT) during pregnancy on the neurocognitive development of infants exposed to the drug.
Article Abstract
Hepatitis B virus (HBV) infection is a global health issue. Mother-to-child transmission (MTCT) is the most prominent route for chronic HBV infection in Asian countries. Although standard immunoprophylaxis has been effective in preventing MTCT, a significantly higher rate of MTCT has been observed among mothers with high levels of viremia. Tenofovir disoproxil, telbivudine (LdT), and lamivudine, used in third trimester, have been shown to significantly reduce MTCT of HBV for highly viremic mothers. Although the efficacy and short-term safety of LdT in preventing MTCT have been demonstrated in several large cohort studies in recent years, fewer data exist on the safety assessment of infants' neurocognitive development after fetal exposure to LdT. Therefore, we conducted a prospective cohort study to investigate the effect of LdT on infants' neurocognitive development.
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| http://dx.doi.org/10.1016/j.cgh.2020.04.056 | DOI Listing |
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