Inspired by nature, humankind has been able to attain significant achievements in the drug and food industries. Particularly, medicinal plants are a rich source of medicinal, cosmetic, sanitary, and aromatic substances. Genus Ferula from the Apiaceae family is a plant genus that possesses over 170 species, which have been carefully documented with regard to their medicinal properties. Ferula spp. affects many body organs, and their respective functions, in humans, such as the immune system, gastrointestinal tract, genitourinary, endocrine, respiratory, cardiovascular, nervous system, bone (skeleton), and teeth. In spite of the benefits, ferulosis (Ferula toxicity) is an important aspect of Ferula consumption in humans and animals. Hemorrhagic problems and infertility are important signs of ferulosis. In this review, we have described all of the effects of the active ingredients of Ferula spp. and their mechanisms of actions, when known, based on an extensive literature review. Thus, our review opens a window of the benefits of Ferula as a phyto-pharmaceutical and its therapeutic applications in pharmacy, dentistry, and medicine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/1389557520666200505125618 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Optimization and Chemical Characterization of Extracts Obtained from var. Aerial Parts and Roots and Their Neuroprotective Evaluation.
Nutrients
December 2024
Foodomics Laboratory, Instituto de Investigacion en Ciencias de la Alimentacion (CIAL), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Nicolas Cabrera 9, 28049 Madrid, Spain.
Background/objectives: The genus has been traditionally used for the treatment of various illnesses, but the potential of var. against different Alzheimer's disease (AD) hallmarks has never been achieved.
Methods: In this work, a pressurized liquid extraction (PLE) method was optimized to extract L.
Isotschimgine promotes lifespan, healthspan and neuroprotection of Caenorhabditis elegans via the activation of nuclear hormone receptors.
Biogerontology
October 2024
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Isotschimgine (ITG) is a bornane-type monoterpenoid derivative naturally occurring in genus Ferula plants and propolis. Its effects on aging and the underlying mechanisms are not yet well understood. This study employed Caenorhabditis elegans (C.
View Article and Find Full Text PDFA Comprehensive Review of the Pharmacological Effects of Genus Ferula on Central Nervous System Disorders.
Cent Nerv Syst Agents Med Chem
July 2024
Department of Physiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Background: Plants of the genus Ferula have long been used to treat neurological diseases such as Alzheimer's disease (AD), pain, depression, and seizures. The main compounds include coumarins, monoterpenes, sulfide compounds, and polyphenol compounds, which can improve the functioning of the nervous system.
Objective: This article has been compiled with the aim of collecting evidence and articles related to the Ferula effects on central nervous system disease.
Antiviral Effect of Ferula Plants and their Potential for Treatment of COVID-19: A Comprehensive Review.
Curr Pharm Biotechnol
July 2024
Department of Physiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Viral diseases have always been a threat to mankind throughout history, and many people have lost their lives due to the epidemic of these diseases. In recent years, despite the progress of science, we are still witnessing a pandemic of dangerous diseases such as COVID-19 all over the world, which can be a warning for humanity. Ferula is a genus of flowering plants commonly found in Central Asia, and its species have shown antiviral activity against a variety of viruses, including respiratory syncytial virus, Herpes simplex virus type 1, influenza, human immunodeficiency virus, hepatitis B, and coronaviruses.
View Article and Find Full Text PDFSesquiterpenes and Sesquiterpene Derivatives from : Their Chemical Structures, Biosynthetic Pathways, and Biological Properties.
Antioxidants (Basel)
December 2023
The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
is a genus of flowering plants known for its edible and medicinal properties. Since ancient times, many species of have been used in traditional medicine to treat various health issues across countries, such as digestive disorders, respiratory problems, and even as a remedy for headaches and toothaches. In addition, they are also used as a flavoring agent in various cuisines.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!