Objectives: We aimed to evaluate the proportional values of maximum standardized uptake value (SUV) for cervical lymph nodes on F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for prediction of the presence of metastasis in patients with larynx squamous cell cancer (LSCC).
Methods: This retrospective study involved 43 patients with LSCC. All patients underwent resection of the primary tumor and neck dissection within 4 weeks after undergoing F-FDG PET/CT examinations. Receiver operating characteristic (ROC) analysis was performed to evaluate the lymph node SUV/primary tumor SUV (SUVLN/SUVPT), lymph node SUV/aortic SUV (SUVLN/SUVA), and lymph node SUV/ liver SUV (SUVLN/SUVL) ratios for diagnosis of lymph node metastasis.
Results: SUVLN/SUVA, SUVLN/SUVL, and SUVLN/SUVPT rates were significantly higher in metastatic lymph nodes compared to non-metastatic nodes. ROC analysis for metastasis showed that the cut-off thresholds were 3.87 for SUVLN; 1.78 for SUVLN /SUVA; 1.08 for SUVLN/SUVL; and 0.36 for SUVLN/SUVPT. The diagnostic sensitivity, specificity and AUC were 83.7%, 77%, 0.856 for SUVLN; 79.7%, 84%, 1.78 for SUVLN/SUVA; 84.1%, 76%, 0.833 for SUVLN/SUVL; and 53.6%, 76%, 0.666 for SUVLN/SUVPT, respectively.
Conclusion: SUVLN/SUVA, SUVLN/SUVL, and SUVLN/SUVPT ratios can be safely used for diagnosis of cervical lymph node metastasis in patients with LSCC.
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| http://dx.doi.org/10.4274/mirt.galenos.2019.92300 | DOI Listing |
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