AI Article Synopsis
- The study evaluated the use of gadobenate-enhanced MRI to predict microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC).
- Significant imaging differences were found between MVI-positive and MVI-negative groups, particularly in tumor characteristics like rim enhancement and peritumoral hypointensity.
- The combination of rim enhancement in the arterial phase and peritumoral hypointensity in the hepatobiliary phase were identified as key independent risk factors for MVI, with high specificity but lower sensitivity in prediction.
Article Abstract
Purpose: To assess the accuracy of gadobenate-enhanced MRI for predicting microvascular invasion (MVI) in patients operated for hepatocellular carcinoma (HCC).
Methods: The 164 patients who met the inclusion criteria were assigned to one of two groups: the MVI-positive group and the MVI-negative group. Imaging results were compared between the two groups using the Kruskal test, chi-square test, independent sample t test, and logistic regression analysis.
Results: Differences in the capsule (p = 0.037) and margin (p = 0.004) of the tumor, rim enhancement (p = 0.002), peritumoral enhancement in the arterial phase (p < 0.001), and peritumoral hypointensity in the hepatobiliary phase (HBP) (p < 0.001) were statistically significant. The results of multivariate analysis identified rim enhancement in the arterial phase (odds ratio (OR) = 2.115; 95% confidence interval (CI), 1.002-4.464; p = 0.049) and peritumoral hypointensity in the HBP (OR = 5.836; 95% CI, 2.442-13.948; p < 0.001) as independent risk factors for MVI. Use of the two predictors in combination identified 32.79% (20/61) of HCCs with MVI with a specificity of 95.15% (98/103).
Conclusions: Rim enhancement in the arterial phase and peritumoral hypointensity in the HBP were identified as independent risk factors for MVI in patients with HCC.
Key Points: • Rim enhancement in the arterial phase and peritumoral hypointensity in the hepatobiliary phase were independent risk factors for microvascular invasion in patients with HCC. • Use of the two predictors in combination had a sensitivity of 32.79% and a specificity of 95.15% for predicting microvascular invasion.
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| http://dx.doi.org/10.1007/s00330-020-06895-6 | DOI Listing |
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