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Utilizing wastewater surveillance to model behavioural responses and prevent healthcare overload during "Disease X" outbreaks.
Emerg Microbes Infect
December 2025
National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, People's Republic of China.
Article Synopsis
- During the COVID-19 pandemic, healthcare systems were overwhelmed, and this study examined how spontaneous avoidance behaviors influenced the spread of infectious diseases through wastewater virus surveillance.
- The researchers developed the Su-SEIQR model to analyze these behaviors alongside COVID-19 data from Beijing and Hong Kong, confirming that collective avoidance helped lower infection peaks, though its overall impact on public health was limited.
- By incorporating healthcare capacity constraints, the model aims to advise public behaviors during outbreaks, offering valuable insights for future public health policies and the management of potential new viruses.
Investigation of paeonol in dermatological diseases: an animal study review.
Front Pharmacol
November 2024
Plastic Surgery, Pikeli Medical Aesthetics, Wuhan, China.
Article Synopsis
- Cortex Moutan, the root bark of the buttercup plant, has been used in Chinese medicine for centuries for its purported heat-clearing and anti-inflammatory properties.
- Paeonol, a key bioactive compound derived from Cortex Moutan, shows promise in treating various skin conditions by reducing inflammation and skin damage.
- The review discusses paeonol's properties, its mechanisms against skin diseases, and potential improvements in its clinical use through advanced extraction and formulation techniques.
Metabolic reprogramming and AMPK activation: Key players in the therapeutic effects of Cooling Blood and Detoxicating Formular on psoriasis.
J Ethnopharmacol
January 2025
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing Key Laboratory of Clinic and Basic Research with Traditional Chinese Medicine on Psoriasis, Beijing, 100010, China. Electronic address:
Ethnopharmacological Relevance: Cooling Blood and Detoxicating Formular (CBDF) based on the theory of cooling blood and dosing detoxification, is a useful traditional Chinese medicine (TCM) medication for psoriasis with blood-heat syndrome.
Aim Of The Study: Investigate the active constituents and mechanisms of the CBDF for the treatment of psoriasis.
Materials And Methods: UPLC-Q-Orbitrap-HRMS technique was used to analyse the ingredients of CBDF absorbed into plasma and skin tissue.
Strategic deactivation of mRNA COVID-19 vaccines: New applications for siRNA therapy and RIBOTACs.
J Gene Med
September 2024
Independent Researcher, Eagleville, Pennsylvania, USA.
Article Synopsis
- The development of mRNA vaccines like Pfizer-BioNTech and Moderna in 2020 overcame challenges related to mRNA instability and immunity, marking a key advancement in vaccine technology.
- The paper discusses improvements in mRNA stability and efficiency through nucleoside modifications and design elements, while raising concerns about the widespread distribution of the vaccines leading to potential inflammatory responses and safety issues.
- It suggests exploring small interfering RNA (siRNA) and ribonuclease targeting chimeras (RIBOTACs) as methods to target and degrade excess vaccine mRNA, which could help prevent harmful spike protein production and reduce side effects.
Cyclo(L-Pro-L-Trp) from Chilobrachys jingzhao alleviates formalin-induced inflammatory pain by suppressing the inflammatory response and inhibiting TRAF6-mediated MAPK and NF-κB signaling pathways.
Int Immunopharmacol
September 2024
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China; National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
Chronic pain has emerged as a significant public health issue, seriously affecting patients' quality of life and psychological well-being, with a lack of effective pharmacological treatments. Numerous studies have indicated that macrophages play a crucial role in inflammatory pain, and targeting neuro-immune interactions for drug development may represent a promising direction for pain management. Chilobrachys jingzhao (C.
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