Earlier genetic and inhibitor studies showed that epigenetic regulation of gene expression is critical for malaria parasite survival in multiple life stages and a promising target for new antimalarials. We therefore evaluated the activity of 350 diverse epigenetic inhibitors against multiple stages of We observed ≥90% inhibition at 10 μM for 28% of compounds against asexual blood stages and early gametocytes, of which a third retained ≥90% inhibition at 1 μM.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318029 | PMC |
| http://dx.doi.org/10.1128/AAC.02523-19 | DOI Listing |
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