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Interplay between genetic risk and built neighborhood conditions as predictor of BMI across the transition into adulthood.
Obesity (Silver Spring)
January 2025
Faculty of Behavioral and Social Sciences, Department of Pedagogy and Educational Sciences, University of Groningen, Groningen, the Netherlands.
Objective: We examined BMI development across changes in the built environment during the transition from adolescence to young adulthood and explored the moderating role of genetic risk.
Methods: We used longitudinal data from individuals aged 16 to 25 years in the TRacking Adolescents' Individual Lives Survey (TRAILS) that we linked to built environment data for 2006, 2010, and 2016 from the Geoscience and Health Cohort Consortium (GECCO). We fitted a latent growth model of BMI and examined associations of changes in fast-food restaurant density and walkability with changes in BMI (n = 2735), as well as interactions of changes in fast-food restaurant density and walkability with genetic risk (n = 1676).
Subsets of extraocular motoneurons produce kinematically distinct saccades during hunting and exploration.
Curr Biol
January 2025
Department of Neuroscience, Physiology & Pharmacology, UCL, Gower Street, London WC1E 6BT, UK. Electronic address:
Animals construct diverse behavioral repertoires by moving a limited number of body parts with varied kinematics and patterns of coordination. There is evidence that distinct movements can be generated by changes in activity dynamics within a common pool of motoneurons or by selectively engaging specific subsets of motoneurons in a task-dependent manner. However, in most cases, we have an incomplete understanding of the patterns of motoneuron activity that generate distinct actions and of how upstream premotor circuits select and assemble such motor programs.
View Article and Find Full Text PDFA novel sequential endocardial mapping strategy for locating atrial fibrillation sources based on repetitive conduction patterns: An in-silico study.
J Mol Cell Cardiol Plus
March 2024
Department of Physiology, Maastricht University, Universiteitssingel 50, Maastricht 6229ER, Netherlands.
Background: In persistent atrial fibrillation (AF), localized extra-pulmonary vein sources may contribute to arrhythmia recurrences after pulmonary vein isolation. This in-silico study proposes a high-density sequential mapping strategy to localize such sources.
Method: Catheter repositioning was guided by repetitive conduction patterns, moving against the prevailing conduction direction (upstream) toward the sources.
Global surgery and climate change: how global surgery can prioritise both the health of the planet and its people.
BMC Surg
January 2025
Global Surgery Division, Department of Surgery, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Climate change is an emerging global health crisis, disproportionately affecting low- and middle-income countries (LMICs) where health outcomes are increasingly compromised by environmental stressors such as pollution, natural disasters, and human migration. With a focus on promoting health equity, Global Surgery advocates for expanding access to surgical care and enhancing health outcomes, particularly in resource-limited and disaster-affected areas like LMICs. The healthcare industry-and more specifically, surgical care-significantly contributes to the global carbon footprint, primarily through resource-intensive settings, i.
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