AI Article Synopsis
- Rosacea is a chronic skin condition linked to various systemic diseases, but its relationship with cardiometabolic disease (CMD) is debated.
- A systematic review and meta-analysis of 13 studies involving over 50,000 patients revealed that those with rosacea had higher rates of dyslipidemia and hypertension, along with elevated cholesterol and blood pressure levels.
- However, rosacea did not show a significant link to ischemic heart disease, stroke, diabetes, or high-density lipoprotein levels, suggesting the need for CMD screening in rosacea patients for early diagnosis and treatment.
Article Abstract
Background: Rosacea is recognized as a chronic inflammatory cutaneous disorder associated with multiple systemic illnesses. However, the association between rosacea and cardiometabolic disease (CMD) remains controversial.
Objective: To evaluate the association between rosacea and CMD by a systematic review and meta-analysis.
Methods: A comprehensive search of studies published before October 16, 2019, was performed in databases of PubMed, Embase, Cochrane Library, and Web of Science. The pooled risk ratios or standardized mean differences were calculated.
Results: Thirteen studies were included, representing 50,442 patients with rosacea. Patients with rosacea had higher prevalence of dyslipidemia, higher prevalence of hypertension, higher total cholesterol, higher low-density lipoprotein, higher triglycerides, higher systolic blood pressure, higher diastolic blood pressure, and higher fasting blood glucose. Rosacea was not associated with ischemic heart disease, stroke, diabetes, and high-density lipoprotein.
Limitations: No subgroup analysis could be performed according to the subtypes and severity of rosacea.
Conclusions: Rosacea showed a correlation with hypertension and dyslipidemia but not with ischemic heart disease, stroke, or diabetes. We advocate screening for CMD indicators among patients with rosacea, which may be helpful for diagnosis and appropriate treatment at an early stage of disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jaad.2020.04.113 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ultrasound-Guided Stellate Ganglion Block Combined with Pharmacological Treatment for Rosacea: A Report of Two Cases.
Patient Prefer Adherence
December 2024
Department of Anesthesiology, the Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, Hubei, 443002, People's Republic of China.
Rosacea is a chronic inflammatory disease primarily affecting the central facial region, significantly involving the facial blood vessels and the sebaceous gland units associated with hair follicles. The stellate ganglion block (SGB) technique can restore balance to autonomic nervous function by interrupting the impulse conduction of preganglionic and postganglionic sympathetic nerve fibers, thereby alleviating excessive peripheral blood vessel contraction, enhancing tissue blood supply, balancing hormone secretion, and modulating immune responses. SGB has demonstrated remarkable efficacy in treating various skin conditions affecting the head, face, and neck.
View Article and Find Full Text PDFAgonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation.
Sci Transl Med
December 2024
Department of Dermatology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Activation of dermal mast cells through the Mas-related G protein-coupled receptor B2 receptor (MrgprB2 in mice and MrgprX2 in humans) is a key component of numerous inflammatory skin diseases, including dermatitis and rosacea. Sensory neurons actively suppress mast cell activation through the regulated release of glutamate, resulting in reduced expression of as well as genes associated with proteins found in mast cell granules. To determine whether exogenous glutamate receptor agonism could suppress mast cell function, we determined that mast cells have relatively selective expression of the glutamate receptor ionotropic, kainate 2 (GluK2).
View Article and Find Full Text PDFThe causal relationship between negative emotions and inflammatory dermatoses: a bidirectional Mendelian randomization study.
Postgrad Med J
December 2024
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
Purpose: Observational studies have suggested a potential link between emotions and inflammatory dermatoses. However, research on the causal relationship between different types of emotions and inflammatory dermatoses is lacking. This study is aimed to investigate the causal relationship between negative emotions and inflammatory dermatoses through Mendelian randomization (MR) analysis.
View Article and Find Full Text PDFThe Prevalence and Clinical Significance of Skin Manifestations in Parkinson's Disease Patients.
Dermatol Pract Concept
October 2024
Department of Neurology, University of Health Sciences, Ankara Bilkent City Hospital, Çankaya/Ankara, Türkiye.
Background: Parkinson's disease (PD) is primarily characterized by motor symptoms, but non-motor symptoms, including skin manifestations, are increasingly recognized. These remain underexplored despite their potential impact on quality of life.
Objectives: This study aimed to evaluate the prevalence and clinical features of skin findings in PD patients, with a focus on identifying potential pathogenetic links between dermatological conditions and PD.
Serum Biomarkers IL-6 and HIF-1α in Rosacea: Assessing Their Significance in Disease Pathogenesis and Telangiectasia Formation.
Dermatol Pract Concept
October 2024
Dermatology Clinic, University of Health Sciences, Etlik City Hospital, Ankara, Turkey.
Introduction: Rosacea, a chronic inflammatory disease primarily affecting the central area of the face, is a complex condition whose mechanisms are still not fully understood. However, research has indicated a positive correlation between two molecules: hypoxia-inducible factor-1α (HIF-1α) and interleukin-6 (IL-6). The levels of HIF-1α in rosacea patients have yet to be assessed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!