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Genetic predisposition to nephropathy and associated cardiovascular disease in people with type 1 diabetes: role of the angiotensinI-converting enzyme (ACE), and beyond; a narrative review.
Cardiovasc Diabetol
December 2024
INSERMU1138-Centre de Recherche Des Cordeliers, Paris Cite University, Sorbonne University, 75006, Paris, France.
Article Synopsis
- Diabetic nephropathy is closely linked to persistent high blood sugar levels, resulting in both kidney and heart vascular issues, particularly in type 1 diabetes, where genetics play a significant role in risk.
- Extensive research, including genome-wide association studies (GWAS), has identified the angiotensin I-converting enzyme (ACE) gene as a major factor in susceptibility and prognosis for diabetic nephropathy.
- Despite various studies identifying genetic variants like ACE I/D polymorphism and others, no major gene has been conclusively linked, and the effects observed remain relatively modest.
Clinicopathological Significance of Extranodal Adipose Tissue Invasion in Metastatic Lymph Nodes in Patients With Prostate Cancer.
Prostate
November 2024
Department of Pathology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
Background: Lymph node (LN) metastasis is a poor prognostic factor in patients with prostate cancer. Elucidating the mechanisms underlying cancer progression in the metastatic microenvironment of LNs is crucial to establishing novel therapies. Adipocytes interact with cancer cells and regulate cancer progression.
View Article and Find Full Text PDFAdiponectin as a biomarker in liver cirrhosis-A systematic review and meta-analysis.
Eur J Clin Invest
January 2025
2nd Department of Internal Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Article Synopsis
- Adiponectin is a promising non-invasive biomarker for liver cirrhosis, reflecting inflammation and metabolic changes, but its role remains unclear due to conflicting findings.
- A systematic review was conducted using 16 studies with 2617 participants, finding that adiponectin levels were significantly higher in liver cirrhosis patients, particularly in those classified as Child-Pugh B.
- The study concludes that while adiponectin is elevated in advanced liver cirrhosis, there are no significant differences when compared to hepatocellular carcinoma (HCC) patients, highlighting its potential as a diagnostic and prognostic tool.
Serum Adiponectin Is Elevated in Critically Ill Patients with Liver Disease and Associated with Decreased Overall Survival.
Biomedicines
September 2024
Department for Gastroenterology, Metabolic Disorders and Intensive Care Medicine, RWTH-University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
Background: Adiponectin, an adipokine with anti-inflammatory properties, has been implicated in various liver diseases. This study aimed to elucidate the prognostic value of serum adiponectin levels in critically ill patients with liver disease.
Methods: This observational study included 161 critically ill patients admitted to the medical ICU of RWTH Aachen University Hospital due to acute liver failure or decompensated advanced chronic liver disease.
Obesity-Associated Breast Cancer: Analysis of Risk Factors and Current Clinical Evaluation.
Adv Exp Med Biol
September 2024
Faculty of Medicine, Department of General Surgery, Gazi University, Besevler, Ankara, Turkey.
Several studies show that a significantly stronger association is obvious between increased body mass index (BMI) and higher breast cancer incidence. Additionally, obese and postmenopausal women are at higher risk of all-cause and breast cancer-specific mortality compared with non-obese women with breast cancer. In this context, increased levels of estrogens, excessive aromatization activity of the adipose tissue, overexpression of pro-inflammatory cytokines, insulin resistance, adipocyte-derived adipokines, hypercholesterolemia, and excessive oxidative stress contribute to the development of breast cancer in obese women.
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