Background: Personality traits, coping styles, and health-related behaviors show associations with various aspects of health. However, integrative life-course investigations of pathways by which these factors might affect later cumulative physiological health risk remain sparse.
Purpose: To investigate prospective associations of personality traits via coping styles and health-related behaviors on allostatic load in a national sample.
Methods: Using data from the Midlife in the United States study (MIDUS; N = 1,054), path analyses were used to test direct and indirect associations (via coping styles, smoking, frequency of alcohol consumption, leisure-time physical activity, and perceptions of activity) of personality traits on a latent measurement model of allostatic load informed by 10 biomarkers associated with cardiovascular, inflammation, glucose, and lipid subsystems.
Results: Direct 10 year associations of greater conscientiousness on healthier allostatic load and greater extraversion on less healthy allostatic load were observed. Consistent with hypothesized behavioral pathways, relationships between conscientiousness and extraversion on allostatic load were prospectively mediated by greater perceptions of activity. Physical activity and more frequent alcohol use were associated with healthier allostatic load but did not act as prospective mediators.
Conclusions: The results provide further evidence of conscientiousness' standing as a marker of health via cumulative physiological health. Moreover, a greater perception of activity was identified as a pathway through which conscientious individuals experienced healthier physiological profiles over time. Examining a more detailed picture of the psychosocial mechanisms leading to development of health risk, as was found with perceptions of activity, remains an important area for future research.
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http://dx.doi.org/10.1093/abm/kaaa024 | DOI Listing |
Pain Rep
February 2025
Department of Physical Medicine & Rehabilitation, College of Medicine, University of Florida, Gainesville, FL, USA.
Introduction: Factors contributing to individual differences in knee osteoarthritis remain elusive. Dispositional traits and socioeconomic status are independent predictors of mental and physical health, although significant variability remains. Dispositional traits serve as the biological interface for life experiences.
View Article and Find Full Text PDFPLoS One
December 2024
Guangzhou Development Research Institute, Guangzhou University, Guangzhou, China.
The female advantage in life expectancy sits uneasily with female disadvantage in health and well-being in later life compared to their male counterparts. This health disparity has been suggested to rest on sex difference in allostatic load (AL). We aim to delineate the sex-specific age trajectories of AL among midlife and older adults in China and to interpret the contradiction between the female advantage in life expectancy and their disadvantage in health in later life from the perspective of physiological dysregulation.
View Article and Find Full Text PDFThe Atlantic wolffish (Anarhichas lupus) is a cold-water fish with potential for aquaculture diversification. To unveil the mechanisms underlying the compromised growth in Atlantic wolffish when reared at higher temperatures, we investigated the relationship between temperature, growth rate, aerobic capacity, stress biomarkers, and gut barrier function. Juveniles acclimated to 10°C were maintained at 10°C (control) or exposed to 15°C for either 24 h (acute exposure) or 50 days (chronic exposure).
View Article and Find Full Text PDFGen Hosp Psychiatry
December 2024
Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan; Psychiatric Research Center, Taipei Medical University Hospital, Taipei, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Objective: Allostatic load refers to the pathophysiological consequences of uncompensated adaptation to chronic stress. Few studies have investigated the effect of allostatic load on cardiac health in patients with serious mental disorders (SMDs), a population at high risk of cardiac mortality. Herein we evaluated associations between allostatic load and cardiac structure and function in young adults with SMDs.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
December 2024
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478.
Genes involved in regulating the hypothalamic-pituitary-adrenal (HPA) axis, including the glucocorticoid receptor (GR), are linked to various stress-related psychopathologies including bipolar disorder as well as other mood and trauma-related disorders. The protein product of the cell cycle gene, is a GR interaction partner in peripheral cells. However, the precise roles of SKA2 in stress and GR signaling in the brain, specifically in nonreplicating postmitotic neurons, and its involvement in HPA axis regulation remain unclear.
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