AI Article Synopsis
- Early afterdepolarization (EAD) contributes significantly to long QT syndrome (LQTS), but understanding its origins has been challenging for decades.
- This research utilizes the Luo-Rudy ventricular myocyte model and nonlinear dynamics to analyze the conditions necessary for EAD occurrence and the impact of physiological parameters.
- The findings include establishing conditions for EAD and deriving the normal form of Hopf bifurcation, which helps determine if the bifurcation is subcritical or supercritical, along with the characteristics of EAD oscillations.
Article Abstract
Early afterdepolarization (EAD) is a major arrhythmogenic factor in the long QT syndrome (LQTS), whose conditions for genesis have puzzled people for several decades. Here, we employ the phase I Luo-Rudy ventricular myocyte model to investigate EAD using methods from nonlinear dynamics and provide valuable insights into EAD genesis from a physical perspective. Two major results are obtained: (i) Sufficient parametric conditions for EAD are analytically determined and then used to analyze in detail the effects of the physiological parameters. (ii) The normal form of the Hopf bifurcation that leads to EAD is derived and then used to determine whether the Hopf bifurcation is subcritical or supercritical for EAD genesis and the corresponding amplitude and period of the EAD oscillation. Our work here paves the way for further studies of more complicated multi-scale dynamics of EAD and may lead to effective treatments for LQTS arrhythmias.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1063/1.5133086 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Discovery of New Synthetic Routes of Amino Acids in Prebiotic Chemistry.
JACS Au
December 2024
Faculty of Synthetic Biology, Shenzhen University of Advanced Technology, Shenzhen 518055, China.
The origin of life on Earth remains one of the most perplexing challenges in biochemistry. While numerous bottom-up experiments under prebiotic conditions have provided valuable insights into the spontaneous chemical genesis of life, there remains a significant gap in the theoretical understanding of the complex reaction processes involved. In this study, we propose a novel approach using a roto-translationally invariant potential (RTIP) formulated with pristine Cartesian coordinates to facilitate the simulation of chemical reactions.
View Article and Find Full Text PDF[Paraneoplastic opsoclonus-myoclonus syndrome].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Kemerovo State Medical University, Kemerovo, Russia.
Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disorder characterized by a combination of main symptoms: opsoclonus, myoclonus, ataxia, psychoemotional and behavioral disturbances. OMS can develop in children as a result of immunopathological processes against the background of infectious or oncological pathology and lead to persistent neurological deficit. A case of ten-year observation of paraneoplastic OMS associated with neuroblastoma in a child is presented.
View Article and Find Full Text PDFFractional erbium-doped yttrium aluminum garnet laser-assisted drug delivery: impact of triamcinolone acetonide formulation on drug permeation.
Drug Deliv Transl Res
December 2024
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.
Ablative fractional laser-assisted drug delivery has gained attention as a promising method for enhancing dermal drug absorption and improving therapeutic outcomes in dermatological conditions, particularly for hypertrophic and keloid scars. However, despite the growing number of clinical trials and case reports supporting its efficacy, there remains a scarcity of robust evidence on the topical bioavailability and dermato-pharmacokinetics of drugs in human subjects. This study aimed to examine the enhancement of triamcinolone acetonide (TAC) bioavailability following treatment with a fractional Erbium-Doped Yttrium Aluminum Garnet (Er: YAG) laser.
View Article and Find Full Text PDFGlobal prevalence, resistance rates, and underlying resistance mechanisms of clinical Mycoplasma and Ureaplasma species.
J Appl Microbiol
December 2024
Department of Dermatology, School of Medicine, University of Pretoria, South Africa.
Mycoplasmas are significant pathogens in human health, implicated in a range of clinical conditions from respiratory infections to urogenital disorders. Their resistance to commonly used antibiotics poses a substantial challenge to treatment and control. This study aims to provide a comprehensive overview of the global distribution of clinical mycoplasmas, elucidate their resistance to various antibiotics, and identify the genetic and molecular mechanisms underlying their resistance.
View Article and Find Full Text PDFMechanisms of microbiota-gut-brain axis communication in anxiety disorders.
Front Neurosci
December 2024
Department of Clinical Laboratory, Neijiang Central District People's Hospital, Neijiang, Sichuan, China.
Anxiety disorders, prevalent mental health conditions, receive significant attention globally due to their intricate etiology and the suboptimal effectiveness of existing therapies. Research is increasingly recognizing that the genesis of anxiety involves not only neurochemical brain alterations but also changes in gut microbiota. The microbiota-gut-brain axis (MGBA), serving as a bidirectional communication pathway between the gut microbiota and the central nervous system (CNS), is at the forefront of novel approaches to deciphering the complex pathophysiology of anxiety disorders.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!