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Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip. | LitMetric

AI Article Synopsis

  • * Despite high cure rates with direct-acting antivirals, those with severe liver damage still face a higher risk of HCC after treatment.
  • * The review explores how HCV contributes to ongoing liver damage through various mechanisms, emphasizing the need for new biomarkers and treatment strategies to prevent cancer progression.

Article Abstract

Chronic infection with hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC). Novel treatments with direct-acting antivirals achieve high rates of sustained virologic response; however, the HCC risk remains elevated in cured patients, especially those with advanced liver disease. Long-term HCV infection causes a persistent and accumulating damage of the liver due to a combination of direct and indirect pro-oncogenic mechanisms. This review describes the processes involved in virus-induced disease progression by viral proteins, derailed signaling, immunity, and persistent epigenetic deregulation, which may be instrumental to develop urgently needed prognostic biomarkers and as targets for novel chemopreventive therapies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246584PMC
http://dx.doi.org/10.3390/ijms21093057DOI Listing

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