Background And Objectives: The purpose of this study was to assess efficacy and safety of a new patterned theta burst stimulation algorithm of DBS with the aim of expanding the therapeutic window and clinical benefit in PD.
Methods: In this single-center, randomized, double-blind, clinical short-term trial, unilateral conventional subthalamic DBS was compared with unilateral patterned stimulation algorithms with intraburst high- or low-frequency theta burst stimulation in 17 PD patients.
Results: There were no serious adverse events with theta burst stimulation. During monopolar review, conventional subthalamic DBS and high-frequency theta burst stimulation were comparable, but low-frequency theta burst stimulation differed by requiring higher stimulation amplitudes for symptom reduction, but a larger therapeutic window. High- and low-frequency theta burst stimulation with adapted stimulation amplitude were effective in PD symptom reduction with differential effects on akinesia and tremor, depending on the theta burst stimulation mode.
Conclusions: Theta burst stimulation is a safe and effective stimulation mode with potential future application opportunities. © 2020 International Parkinson and Movement Disorder Society.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/mds.28083 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Low-Frequency rTMS in the Management of Auditory Hallucination Nonresponsive to ECT, Clozapine, and Continuous Theta Burst Stimulation: A Case Study.
J ECT
October 2024
Department of Psychiatry, King George's Medical University, Lucknow, Uttar Pradesh, India
Effects of Repetitive Transcranial Magnetic Stimulation on Poststroke Hemineglect: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
Neurorehabil Neural Repair
December 2024
Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Background: Although various repetitive transcranial magnetic stimulation (rTMS) and theta burst stimulation (TBS) protocols are used, their comparative effectiveness for treating poststroke hemineglect remains unassessed.
Objective: To investigate rTMS and TBS effects on clinical outcomes in poststroke hemineglect through a systematic review and network meta-analysis.
Methods: We searched PubMed, EMBASE, and Cochrane Library databases up to March 7, 2024, for trials on rTMS or TBS in poststroke hemineglect.
Effectiveness of sequential bilateral repetitive transcranial stimulation versus bilateral theta burst stimulation for patients with treatment-resistant depression (BEAT-D): A randomized non-inferiority clinical trial.
Brain Stimul
December 2024
Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan; Shinjuku-Yoyogi Mental Lab Clinic, 5-27-5 Sendagaya, Shibuyaku, Tokyo, 151-0051, Japan; Department of Psychiatry, International University of Health and Welfare, Mita Hospital, 1-4-3 Mita, Minato-ku, Tokyo, 108-8329, Japan. Electronic address:
Background: Bilateral repetitive transcranial magnetic stimulation (BL-rTMS) over the dorsolateral prefrontal cortex is effective for treatment-resistant depression (TRD). Owing to a shorter treatment time, bilateral theta burst stimulation (BL-TBS) can be more efficient protocol. The non-inferiority of BL-TBS to BL-rTMS was established in late-life TRD; however, this has not been determined in adults of other age groups.
View Article and Find Full Text PDFIntraoperative Electroencephalogram Frontal Low Alpha Power for Predicting Postoperative Delirium in Elderly Patients after Orthopedic Surgery: A Prospective Cohort Study.
Ann Ital Chir
December 2024
Department of Anesthesiology & Key Laboratory of Clinical Science and Research, Zhongda Hospital, Southeast University, 210009 Nanjing, Jiangsu, China.
Aim: Postoperative delirium (POD) is a common complication with significant adverse effects in elderly patients. Electroencephalography (EEG) provides a promising approach for predicting the risk of POD. This study aims to elucidate the correlation between intraoperative EEG spectrum and the incidence of POD in elderly patients undergoing orthopedic surgery.
View Article and Find Full Text PDFGlobal research hotspots and trends of theta burst stimulation from 2004 to 2023: a bibliometric analysis.
Front Neurol
December 2024
Department of Sports Rehabilitation, Beijing Xiaotangshan Hospital, Beijing, China.
Background: Theta burst stimulation (TBS) has garnered widespread attention in the scientific community, but a comprehensive bibliometric analysis of TBS research remains absent. This study aims to fill this gap by elucidating the characteristics, hotspots, and trends in TBS publications over the past 20 years using bibliometric methods.
Methods: We retrieved TBS-related publications from January 1, 2004, to December 31, 2023, from the Web of Science Core Collection (WoSCC).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!