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Early Feasibility Study of a Hybrid Tissue-Engineered Mitral Valve in an Ovine Model.
J Cardiovasc Dev Dis
February 2024
Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA.
Tissue engineering aims to overcome the current limitations of heart valves by providing a viable alternative using living tissue. Nevertheless, the valves constructed from either decellularized xenogeneic or purely biologic scaffolds are unable to withstand the hemodynamic loads, particularly in the left ventricle. To address this, we have been developing a hybrid tissue-engineered heart valve (H-TEHV) concept consisting of a nondegradable elastomeric scaffold enclosed in a valve-like living tissue constructed from autologous cells.
View Article and Find Full Text PDFRole and Clinical Importance of Progressive Changes in Echocardiographic Parameters in Predicting Outcomes in Patients With Hypertrophic Cardiomyopathy.
J Cardiovasc Imaging
April 2023
Division of Cardiology, Department of Internal Medicine, Gyeongsang National University Hospital and Gyeongsang National University School of Medicine, Jinju, Korea.
Background: The prognostic utility of follow-up transthoracic echocardiography (FU-TTE) in patients with hypertrophic cardiomyopathy (HCM) is unclear, specifically in terms of whether changes in echocardiographic parameters in routine FU-TTE parameters are associated with cardiovascular outcomes.
Methods: From 2010 to 2017, 162 patients with HCM were retrospectively enrolled in this study. Using echocardiography, HCM was diagnosed based on morphological criteria.
Assessment of transmitral and left atrial appendage flow rate from cardiac 4D-CT.
Commun Med (Lond)
February 2023
Unit of Cardiovascular Sciences, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Article Synopsis
- Cardiac time-resolved CT (4D-CT) is useful for getting clear anatomical images of the heart but lacks accurate methods for assessing blood flow in conditions like diastolic dysfunction and atrial fibrillation.
- * Researchers created a motion tracking algorithm that differentiates blood flow in the mitral valve and left atrial appendage using 4D-CT images, improving accuracy over previous methods.
- * The new algorithm showed promising results, with similarities in flow measurements between the 4D-CT and MRI methods, particularly for the mitral valve and left atrial appendage, indicating its potential for clinical use.
Preoperative echocardiography predictive analytics for postinduction hypotension prediction.
PLoS One
November 2022
Department of Anesthesiology, Ube Industries Central Hospital, Ube, Yamaguchi, Japan.
Purpose: Hypotension is a risk factor for adverse perioperative outcomes. Preoperative transthoracic echocardiography has been extended for preoperative risk assessment before noncardiac surgery. This study aimed to develop a machine learning model to predict postinduction hypotension risk using preoperative echocardiographic data and compared it with conventional statistic models.
View Article and Find Full Text PDFA 52-year-old woman with a past history of anterior myocardial infarction 15 years previously was found to have a pedunculated mobile thrombus with a narrow stalk originating from the left ventricle, and a huge laminated mural thrombus. Surgical extraction of the two organized thrombi was successfully performed with transmitral approach using a novel, flexible, self-retained, and reusable leaflet retractor, which was originally developed for exposure of the subvalvular apparatus during mitral valve repair. Excellent access, exposure, and visualization of the left ventricle were achieved by this heart valve retractor and an endoscope for removal of a huge mural thrombus.
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