Deep learning based classification of solid lipid-poor contrast enhancing renal masses using contrast enhanced CT.

Objective: Establish a workflow that utilizes convolutional neural nets (CNN) to classify solid, lipid-poor, contrast enhancing renal masses using multiphase contrast enhanced CT (CECT) images and to assess the performance of the resulting network.

Methods: In this institutional review board approved study of 143 patients with predominantly solid, lipid-poor, contrast enhancing renal lesions (46 benign and 97 malignant), patients with a pre-operative multiphase CECT of the abdomen and pelvis obtained between June 2009 and June 2015 were retrospectively queried. Benign renal masses included oncocytoma and lipid-poor angiomyolipoma and the malignant group included clear cell, papillary, and chromophobe carcinomas.Region of interests of whole tumor volumes were manually segmented, and CT phase images with the largest cross-section of the segmented tumor in the axial plane were used for assessment. Post-surgical pathological evaluation was used to establish diagnosis.The segmented images of renal masses were used as input to a CNN. The data were augmented and split into training (83.9%) and validation sets (16.1%) to determine the hyperparameters of the CNN. Thereafter. the performance of the resulting CNN was quantified using eightfold cross-validation.

Results: The CNN-based classifier demonstrated an overall accuracy of 78% (95% confidence interval: 76-80%), sensitivity of 70% (95% confidence interval: 66-74%), specificity of 81% (79-83%) and an area under the curve of 0.82.

Conclusion: A CNN-based classifier to diagnose solid enhancing malignant renal masses based on multiphase CECT images was developed.

Advances In Knowledge: It was established that a CNN-based classifier could be trained to accurately distinguish malignant renal lesions.