AI Article Synopsis
- * These reservoirs may persist because of long-lived infected cells and ongoing viral replication, raising questions about the effectiveness of different ART regimens.
- * The text highlights how various ART combinations impact residual viral levels and the HIV reservoir, suggesting that different drug classes might influence treatment outcomes differently.
Article Abstract
In adherent individuals, antiretroviral therapy (ART) suppresses HIV replication, restores immune function, and prevents the development of AIDS. However, ART is not curative and has to be followed lifelong. Persistence of viral reservoirs forms the major obstacle to an HIV cure. HIV latent reservoirs persist primarily by cell longevity and proliferation, but replenishment by residual virus replication despite ART has been proposed as another potential mechanism of HIV persistence. It is a matter of debate whether different ART regimens are equally potent in suppressing HIV replication. Here, we summarized the current knowledge on the role of ART regimens in HIV persistence, focusing on differences in residual plasma viremia and other virological markers of the HIV reservoir between infected individuals treated with combination ART composed of different antiretroviral drug classes.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290301 | PMC |
| http://dx.doi.org/10.3390/v12050489 | DOI Listing |
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