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Lateral semi-circular canal asymmetry in females with idiopathic scoliosis. | LitMetric

Lateral semi-circular canal asymmetry in females with idiopathic scoliosis.

PLoS One

Department of Orthopaedic Surgery, Musculoskeletal Research Center, Children's Hospital Colorado, Aurora, Colorado, United States of America.

Published: July 2020

AI Article Synopsis

  • Adolescent idiopathic scoliosis (AIS) is a common spinal deformity whose exact genetic causes are still unknown, and this study explored the potential connection between vestibular anatomy, specifically the semicircular canals (SCCs), and AIS using advanced MRI techniques.
  • The research involved creating 3D MRI models of the SCCs in 20 AIS patients and 19 healthy controls, revealing significant side-to-side differences in the lateral SCC orientation between the two groups.
  • The findings suggest that asymmetry in the SCCs of individuals with AIS might lead to abnormal muscle activity, particularly during growth spurts, which could contribute to the progression of scoliosis.

Article Abstract

Purpose: Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal structural deformity that occurs in otherwise normal individuals. Although curve progression and severity vary amongst individuals, AIS can lead to significant cosmetic and functional deformity. AIS etiology has been determined to be genetic, however, exact genetic and biological processes underlying this disorder remain unknown. Vestibular structure and function have potentially been related to the etiopathogenesis of AIS. Here, we aimed to characterize the anatomy of the semicircular canals (SCC) within the vestibular system through a novel approach utilizing T2-weighted magnetic resonance images (MRI).

Methods: Three dimensional, MRI-based models of the SCCs were generated from AIS subjects (n = 20) and healthy control subjects (n = 19). Linear mixed models were used to compare SCC morphological measurements in the two groups. We compared side-to-side differences in the SCC measurements between groups (group*side interaction).

Results: Side-to-side differences in the lateral SCC were different between the two groups [false discovery rate adjusted p-value: 0.0107]. Orientation of right versus left lateral SCC was significantly different in the AIS group compared to the control group [mean side-to-side difference: -4.1°, 95% CI: -6.4° to -1.7°]. Overall, among subjects in the AIS group, the left lateral SCC tended to be oriented in a more horizontal position than subjects in the control group.

Significance: Asymmetry within the SCCs of the vestibular system of individuals with AIS potentially results in abnormal efferent activity to postural muscles. Consequences of this muscular activity during periods of rapid growth, which often coincides with AIS onset and progression, warrant consideration.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190182PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232417PLOS

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