respiTrack: Patient-specific real-time respiratory tumor motion prediction using magnetic tracking.

Purpose: An intraoperative real-time respiratory tumor motion prediction system with magnetic tracking technology is presented. Based on respiratory movements in different body regions, it provides patient and single/multiple tumor-specific prediction that facilitates the guiding of treatments.

Methods: A custom-built phantom patient model replicates the respiratory cycles similar to a human body, while the custom-built sensor holder concept is applied on the patient's surface to find optimum sensor number and their best possible placement locations to use in real-time surgical navigation and motion prediction of internal tumors. Automatic marker localization applied to patient's 4D-CT data, feature selection and Gaussian process regression algorithms enable off-line prediction in the preoperative phase to increase the accuracy of real-time prediction.

Results: Two evaluation methods with three different registration patterns (at fully/half inhaled and fully exhaled positions) were used quantitatively at all internal target positions in phantom: The statical method evaluates the accuracy by stopping simulated breathing and dynamic with continued breathing patterns. The overall root mean square error (RMS) for both methods was between [Formula: see text] and [Formula: see text]. The overall registration RMS error was [Formula: see text]. The best prediction errors were observed by registrations at half inhaled positions with minimum [Formula: see text], maximum [Formula: see text]. The resulting accuracy satisfies most radiotherapy treatments or surgeries, e.g., for lung, liver, prostate and spine.

Conclusion: The built system is proposed to predict respiratory motions of internal structures in the body while the patient is breathing freely during treatment. The custom-built sensor holders are compatible with magnetic tracking. Our presented approach reduces known technological and human limitations of commonly used methods for physicians and patients.