Despite significant progress in research on the treatment and prevention of psychological, behavioral, and health problems, the translation of this knowledge into population-wide benefit remains limited. This paper reviews the state of America's children and families, highlighting the influence of stressful contextual and social conditions on child and family well-being and the concentration of disadvantage in numerous neighborhoods and communities throughout the nation. It then briefly reviews the progress that has been made in pinpointing policies that can reduce stressful contextual conditions such as poverty, discrimination, and the marketing of unhealthful foods and substances. It also describes numerous family and school interventions that have proven benefit in preventing psychological and behavioral problems as diverse as tobacco, alcohol, and other drug use; depression; antisocial behavior; academic failure; obesity prevention; and early childbearing. We argue that progress in translating existing knowledge into widespread benefit will require a nationwide effort to intervene comprehensively in neighborhoods and communities of concentrated disadvantage. We present a strategic plan for how such an effort could be organized. The first step in this organizing would be the creation of a broad and diverse coalition of organizations concerned with advancing public health and well-being. Such a coalition could increase public support both for the policies needed to focus on these disadvantaged areas and the research needed to incrementally improve our ability to help these areas.
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http://dx.doi.org/10.1007/s10567-020-00318-0 | DOI Listing |
Stat Med
February 2025
Department of Biostatistics and Health Data Science, University of Pittsburgh, Pittsburgh, Pennsylvania.
An important aspect of precision medicine focuses on characterizing diverse responses to treatment due to unique patient characteristics, also known as heterogeneous treatment effects (HTE) or individualized treatment effects (ITE), and identifying beneficial subgroups with enhanced treatment effects. Estimating HTE with right-censored data in observational studies remains challenging. In this paper, we propose a pseudo-ITE-based framework for analyzing HTE in survival data, which includes a group of meta-learners for estimating HTE, a variable importance metric for identifying predictive variables to HTE, and a data-adaptive procedure to select subgroups with enhanced treatment effects.
View Article and Find Full Text PDFVet Sci
January 2025
Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.
Camel milk is a valuable food source with unique nutritional properties and potential health benefits. This study investigated the influence of high dietary salt on milk composition and fatty acid (FA) profile as well as insulin regulation in dairy camels. Twelve multiparous female camels were used in a crossover design with two treatments: control concentrate (CON; 1.
View Article and Find Full Text PDFJ Funct Morphol Kinesiol
December 2024
College of Education, National Tsing Hua University, Nanda Campus, No. 521, Nanda Rd., Hsinchu City 300193, Taiwan.
Top badminton players must carefully schedule tournaments to perform well and improve their rankings. This study examines how players plan their tournament participation and whether their scheduling strategies affect their rankings and performance, especially during Olympic and non-Olympic years. Data were extracted from the Badminton World Federation (BWF) ranking system for the top 50 men's and women's singles players from May 2014 to May 2019.
View Article and Find Full Text PDFAdv Mater
January 2025
Hefei National Research Center for Physical Sciences at the Microscale, Department of Materials Science and Engineering, CAS Key Laboratory of Materials for Energy Conversion, University of Science and Technology of China, Hefei, 230026, China.
Electrocatalytic biomass conversion offers a sustainable route for producing organic chemicals, with electrode design being critical to determining reaction rate and selectivity. Herein, a prediction-synthesis-validation approach is developed to obtain electrodes for precise biomass conversion, where the coexistence of multiple metal valence states leads to excellent electrocatalytic performance due to the activated redox cycle. This promising integrated foam electrode is developed via acid-induced surface reconstruction to in situ generate highly active metal (oxy)hydroxide or oxide (MOH or MO) species on inert foam electrodes, facilitating the electrooxidation of 5-hydroxymethylfurfural (5-HMF) to 2,5-furandicarboxylic acid (FDCA).
View Article and Find Full Text PDFJ Pharm Policy Pract
January 2025
School of Medical and Life Sciences, Sunway University, Sunway City, Malaysia.
Vision 2030 represents Saudi Arabia's strategic socio-economic plan aimed at promoting economic diversification and enhancing living standards. Launched in April 2016, this vision describes an innovative healthcare plan to improve services and outcomes. The merits and drawbacks of public hospitals' 'Model of Care' are examined in this study.
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