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Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia.
Am J Physiol Gastrointest Liver Physiol
May 2004
Dept. of Experimental Surgery, Univ. of Rostock, D-18055 Rostock, Germany.
Apoptotic hepatocytes have been demonstrated to represent an important signal for transmigration of leukocytes sequestered in sinusoids during endotoxemia in vivo. Beside leukocytes, platelets and their adhesion to endothelial cells and leukocytes have been implicated in inflammatory liver injury. Using in vivo multifluorescence microscopy, we examined the possibility that hepatocellular apoptosis causes both leukocytes and platelets to colocalize within the sinusoidal microvasculature of endotoxemic livers.
View Article and Find Full Text PDF[Thrombocytopenia and HIV: the role of splenectomy].
Schweiz Med Wochenschr
October 1988
Département de médecine, Hôpital cantonal universitaire de Genève.
Severe thrombocytopenia has been diagnosed in HIV seropositive patients independently of the clinical stage of disease. In view of its immunologic origin, attempts have been made to treat this condition with drugs which have proved effective in the treatment of autoimmune thrombocytopenia, though with little or no beneficial effect to these patients. This communication deals with the observation (5-22 months) of 5 HIV seropositive patients with severe thrombocytopenia who were resistant to steroids, high dose i.
View Article and Find Full Text PDFPlatelet and leukocyte counts and leukocytotoxic and platelet antibodies were studied in 32 patients with autoimmune hemolytic anemia (AHA). Leukopenia was present in 59.4%, thrombocytopenia in 59.
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