AI Article Synopsis
- The study investigated peripheral small-fiber neurotoxicity and pain sensitization in long-term survivors of pediatric acute lymphoblastic leukemia who underwent stem cell transplantation (SCT).
- 25 relapse-free survivors were assessed using a clinical neuropathy score and Quantitative Sensory Testing (QST) to evaluate pain sensitivity and nerve function.
- Findings revealed that 36% of participants had peripheral neuropathy, while 88% showed signs of small fiber dysfunction and more than half experienced heightened sensitivity to pain, indicating a significant long-term impact on their nerve health.
Article Abstract
Purpose: We aimed at describing for the first time peripheral small-fiber neurotoxicity and pain sensitization in survivors of pediatric acute lymphoblastic leukemia after stem cell transplantation (SCT).
Methods: In a cross-sectional, retrospective, single-center study, we assessed 25 relapse-free long-term survivors (median age at SCT: 11 ± 4.9 years; median time between SCT and testing: 8.25 years, 19 males) using a reduced version of the pediatric-modified total neuropathy score for clinical assessment and Quantitative Sensory Testing (QST).
Inclusion Criteria: [Formula: see text] 6 years old at testing, [Formula: see text] 18 years old at time of SCT, [Formula: see text] 1 year between SCT and testing.
Results: Nine patients (36%) had peripheral neuropathy as defined by the clinical red-pmTNS (≥ 4). The QST parameters mechanical pain sensitivity, mechanical detection threshold, thermal sensory limen, vibration detection threshold and pressure pain threshold were significantly abnormal in the survivor cohort (p < 0.0038). Except for one, all survivors showed at least one abnormal QST parameter. When using QST, signs of small and large fiber dysfunction were present in 22 (88%) and 17 (68%) survivors, respectively. More than half of all survivors were found to experience pathologic sensitization to pain.
Conclusions And Implications For Cancer Survivors: Survivors of pediatric acute lymphoblastic leukemia after SCT are at high risk for long-term peripheral neuropathy with a dominating small-fiber and pain sensitization pattern.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363542 | PMC |
| http://dx.doi.org/10.1007/s00432-020-03216-8 | DOI Listing |
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