Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.20506/rst.8.4.462 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Structure and catalytic activity of a dihydrofolate reductase-like enzyme from Leptospira interrogans.
Int J Biol Macromol
January 2025
Center of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand; Center of Excellence in Molecular Crop, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address:
A dihydrofolate reductase (DHFR)-like enzyme from Leptospira interrogans (LiDHFRL) was cloned and the recombinant protein was characterized. Sequence alignment suggested that the enzyme lacked the conserved catalytic residues found in DHFR. Indeed, LiDHFRL did not catalyze the reduction of dihydrofolate by either NADH or NADPH.
View Article and Find Full Text PDFAntibacterial Activity of Crude , , and Methanolic Extracts on serovar Manilae.
Acta Med Philipp
December 2024
Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila.
Background And Objective: Leptospirosis is a disease caused by pathogenic prevalent in tropical countries like the Philippines. Some studies have shown that the role of currently used antibiotics for leptospirosis is unclear since trials have found no significant benefit to patient outcomes compared to placebo. This signals the need for alternative therapies, such as herbal medicines, which may provide effective therapeutic regimens in treating this infection.
View Article and Find Full Text PDFChronic Carriage of Leptospira interrogans Genotype Associated With the Australis Serogroup by Naturally-Infected Hedgehogs (Erinaceus europaeus) at a Wildlife Health Centre in Northwestern France.
Zoonoses Public Health
January 2025
CHUV, Oniris, Nantes, France.
Background: Leptospirosis is a widespread zoonosis caused by bacteria in the genus Leptospira. Basic epidemiological information is crucial to mitigating disease risk but is lacking for leptospirosis; notably, the hosts responsible for maintaining Leptospira remain largely unknown. Frequently observed near human habitations, hedgehogs (Erinaceus europaeus) are taken to wildlife rescue centres when found sick or injured.
View Article and Find Full Text PDFbiofilms: implications for survival, transmission, and disease management.
Appl Environ Microbiol
January 2025
Postgraduate Program in Animal Science in the Tropics - Federal University of Bahia, Salvador, Bahia, Brazil.
Leptospirosis is a zoonotic disease caused by bacteria, affecting humans and a broad range of wild and domestic animals in diverse epidemiological settings (rural, urban, and wild). The disease's pathogenesis and epidemiology are complex networks not fully elucidated. Epidemiology reflects the One Health integrated approach of environment-animal-human interaction, causing severe illness in humans and animals, with consequent public health burdens.
View Article and Find Full Text PDFsp. nov, . sp. nov, . sp. nov, . sp. nov and . sp. nov: five new species isolated from water sources in the Midwestern United States.
Int J Syst Evol Microbiol
January 2025
Infectious Bacterial Diseases Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA, USA.
Isolates of spp. were cultured from water sources at five different sites in central Iowa in the Midwestern United States and characterized by whole-genome sequencing. Isolates were helix-shaped and motile.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!