Synthesis, Characterization, and Biochemical Impacts of Some New Bioactive Sulfonamide Thiazole Derivatives as Potential Insecticidal Agents against the Cotton Leafworm, .

A novel series of anticipated biologically active heterocyclic compounds, such as pyrazole, thiazole, pyridine, acrylamide, thiophene, triazolo[1,5-]pyrimidine, imidazolidine, aminopyrazole, pyrazolo[5,1-][1,2,4]triazine, triazolo[4,3-]pyrimidine, benzo[4,5]imidazo[1,2-]pyrimidine, pyrido[2',3':3,4]pyrazolo[5,1-][1,2,4]triazine, isoxazole, benzo[4,5]imidazo[2,1-][1,2,4]triazine, pyrimidine, pyrido[2',3':3,4]pyrazolo[1,5-]pyrimidine, pyrano[2,3-]pyrimidine, and chromene derivatives, incorporating a sulfonamide-bearing thiazole moiety suitable to utilize as insecticidal agents were synthesized via a versatile, readily accessible cyanoacetanilide, 2-cyano--(4-(-(thiazol-2-yl)sulfamoyl)phenyl)acetamide ().The structures of the newly synthesized compounds were elucidated by IR, MS, H NMR, C NMR, distortionless enhancement by polarization transfer (DEPT), H-H correlation spectroscopy (COSY), heteronuclear multiple bond correlation (HMBC), and heteronuclear single quantum coherence (HSQC) spectral analysis. Toxicological and biochemical parameters and biological aspects of the demonstrated compounds of the synthesized products against the cotton leafworm, , under laboratory conditions were also investigated. Regarding the determined LC and LC values, sulfonamides bearing a thiazole moiety, , , , and , showed the most potent toxic effects with LC values of 49.04, 62.66, 78.62, and 94.90 ppm, respectively, and toxicity index of 100%, 78.26%, 62.38%, and 51.68%, respectively.