AI Article Synopsis
- Cutibacterium acnes (C. acnes), a bacteria usually linked to late postoperative infections, has been found to cause early surgical site infections (SSI) after a change in antibiotic protocols at a hospital.
- A study reviewed patient data from 2007 to 2017, comparing the incidence of early C. acnes SSI across three different antibiotic treatment protocols.
- Results showed that the incidence of C. acnes infections increased from 0% to 4.9% with the new protocol but decreased to 1.7% after reverting to a longer antibiotic treatment, suggesting that prolonged antibiotic use helps prevent these infections.
Article Abstract
Purpose: Cutibacterium acnes (C. acnes) is a gram-positive anaerobic bacillus located in pilosebaceous glands, usually responsible for late postoperative surgical site infections (SSI). A recent study performed in our institution highlighted an unexpected emergence of C. acnes early SSI. One potential explanation was the change of the perioperative antibioprophylaxis (ATB) protocol, which switched from 48 h postoperative cefamandole to intraoperative only cefazoline. The aim of this study was therefore to investigate the influence of the ATB duration on the occurrence of C. acnes early SSI, by comparing the incidence rates during 3 consecutive ATB protocols.
Methods: Between January 2007 and September 2017, all patients who underwent posterior fusion for AIS were retrospectively reviewed. Early C. acnes SSI were reported and compared between 3 periods, during which the ATB protocols were modified. January 2007-February 2012: Intraoperative Cefamandole continued 48 h (protocol 1) March 2012-August 2016: Single shot of intraoperative Cefazoline (protocol 2) September 2016-September 2017: Intraoperative Cefazoline continued 48 h (protocol 3).
Results: Fifty-three early SSI (7.2%) were reported among the 732 posterior AIS fusions included. Global incidence of C. acnes infection was 2.9%. The incidence of C. acnes in early SSI increased from 0 to 4.9% between protocol 1 and 2, but was reduced to 1.7% with protocol 3.
Conclusions: Early C acnes SSI can be explained by the difficulty to eradicate this pathogen with current skin preparation procedures and some Beta-lactam antibiotics tolerance. Longer duration antibioprophylaxis is preferable to prevent from early C. acnes SSI.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00586-020-06427-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the Landscape of Perioperative Immediate Hypersensitivity: A Comprehensive 6-Year Monocentric Observational Analysis on Epidemiology and Risk Factors.
Int Arch Allergy Immunol
November 2024
Anaesthesiology and Critical Care Medicine Department, Croix-Rousse University Hospital, Hospices Civils de Lyon, Lyon, France.
Introduction: Perioperative immediate hypersensitivity (POH) is a rare complication estimated at 1/10,000 anaesthesia. The objective of our study was to investigate the risk factors of POH over a 6-year period in a French teaching hospital.
Materials And Methods: A single-centre retrospective descriptive epidemiological study of patients treated in the operating room from January 2016 to December 2021 with and without POH.
Deep infections after low-velocity ballistic tibia fractures are frequently polymicrobial and recalcitrant.
OTA Int
December 2024
Department of Orthopaedic Surgery, Atrium Health Musculoskeletal Institute, Charlotte, NC.
Objectives: To identify risk factors for developing a fracture-related infection in operatively treated ballistic tibia fractures and to report the microbiologic results of intraoperative cultures.
Design: Retrospective review.
Setting: Level 1 trauma center.
Lower abdominal cyst complicated with suspected infection following INFIX internal fixation for pelvic fracture: a report of two rare cases.
BMC Musculoskelet Disord
August 2024
Department of Orthopedics Surgery, Orthopedic Research Institute, West China Hospital of Sichuan University, Chengdu, China.
Background: The Internal Fixator (INFIX) is a popular method, known for its minimal invasiveness and short operation time, for treating anterior pelvic ring fractures. Studies have shown that postoperative complications may occur, including anterolateral femoral cutaneous nerve injury, the femoral nerve paralysis, and delayed fracture healing. These complications are believed to be related to surgical stimulation, an excessively long lateral end of the connecting rod, a small distance between the screw and bone surface, insufficient pre-bending of the connecting rod, and difficulties in fracture reduction.
View Article and Find Full Text PDFHow can the surgeon choose preoperatively the most appropriate antibiotic prophylaxis vs therapy in pediatric acute appendicitis?
Pediatr Surg Int
July 2024
U.O.C di Chirurgia Pediatrica, A.O.U. Policlinico di Modena, 71 Via del Pozzo, 41121, Modena, Italy.
Introduction: The aim of this study was to find statistically valid criteria to preoperatively divide acute appendicitis into simple and complicated to enable surgeons to administer the most appropriate antibiotic prophylaxis/therapy before surgery.
Materials And Methods: We retrospectively reviewed a cohort of patients who underwent appendectomy from January 2022 to December 2023. Patients included were 0-14 years of age.
Perioperative Infection Prophylaxis With Vancomycin is a Significant Risk Factor for Deep Surgical Site Infection in Spine Surgery.
Spine (Phila Pa 1976)
November 2024
Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY.
Study Design: Retrospective cohort.
Objective: The purpose of this study was to compare the efficacy of cefazolin versus vancomycin for perioperative infection prophylaxis.
Summary Of Background Data: The relative efficacy of cefazolin alternatives for perioperative infection prophylaxis is poorly understood.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!