AI Article Synopsis
- Pancreatic cancer (PC) has a low survival rate and the study explored the role of miR-548t-5p, which was found to be significantly lower in PC tissues compared to normal adjacent tissues.
- * Lower levels of miR-548t-5p were linked to aggressive tumor behavior, while higher levels reduced cancer cell growth and spread.
- * The study identified a pathway where the protein YY1 enhances miR-548t-5p expression, which in turn inhibits CXCL11, a protein that, when elevated, correlates with more severe cancer progression.
Article Abstract
Pancreatic cancer (PC) is a malignant tumor with a poor prognosis and high mortality. However, the biological role of miR-548t-5p in PC has not been reported. In this study, we found that miR-548t-5p expression was significantly decreased in PC tissues compared with adjacent tissues, and that low miR-548t-5p expression was associated with malignant PC behavior. In addition, high miR-548t-5p expression inhibited the proliferation, migration, and invasion of PC cell lines. Regarding the molecular mechanism, the luciferase reporter gene, chromatin immunoprecipitation (ChIP), and functional recovery assays revealed that YY1 binds to the miR-548t-5p promoter and positively regulates the expression and function of miR-548t-5p. miR-548t-5p also directly regulates CXCL11 to inhibit its expression. A high level of CXCL11 was associated with worse Tumor Node Metastasis (TNM) staging in patients with PC, enhancing proliferation and metastasis in PC cells. Our study shows that the YY1/miR-548t-5p/CXCL11 axis plays an important role in PC and provides a new potential candidate for the treatment of PC.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186231 | PMC |
| http://dx.doi.org/10.1038/s41419-020-2475-3 | DOI Listing |
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