AI Article Synopsis
- Recent studies indicate a growing global threat from multidrug-resistant pathogens, particularly Stenotrophomonas maltophilia, which poses risks to healthcare settings.
- An international analysis of this pathogen revealed it is divided into 23 distinct lineages, many of which contain strains capable of varying levels of human virulence.
- Notably, lineage Sm6 was found to have the highest association with human infections and includes key genes linked to virulence and antibiotic resistance, suggesting potential for hospital outbreaks among closely related strains.
Article Abstract
Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184733 | PMC |
| http://dx.doi.org/10.1038/s41467-020-15123-0 | DOI Listing |
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