Pathogenicity Genomic Island-Associated CrpP-Like Fluoroquinolone-Modifying Enzymes among Pseudomonas aeruginosa Clinical Isolates in Europe.

Many transferable quinolone resistance mechanisms have been identified in Gram-negative bacteria. The plasmid-encoded 65-amino-acid-long ciprofloxacin-modifying enzyme CrpP was recently identified in isolates. We analyzed a collection of 100 clonally unrelated and multidrug-resistant clinical isolates, among which 46 were positive for -like genes, encoding five CrpP variants conferring variable levels of reduced susceptibility to fluoroquinolones. These -like genes were chromosomally located as part of pathogenicity genomic islands.