AI Article Synopsis
- A study investigated the link between gastroesophageal reflux disease (GERD) and laryngeal cancer by comparing patients with laryngeal cancer to those without.
- It found that patients with laryngeal neoplasia had higher instances of GERD, showing a positive association with an odds ratio of 1.33.
- After accounting for alcohol use, the association remained significant, with an adjusted odds ratio of 1.29, indicating that GERD may increase the risk of laryngeal cancer regardless of smoking and drinking habits.
Article Abstract
Gastroesophageal reflux disease (GERD) has been hypothesized as a risk factor for development of laryngeal cancer. A case-control study was performed to assess the association of laryngeal neoplasia with GERD. Cases consisted of patients with a history of laryngeal cancer or carcinoma in situ. Controls were patients without neoplasia who matched cases 2:1 on age, sex, race, and smoking history. Univariate and multivariate analyses were performed to assess risk of laryngeal neoplasia and GERD. In total, 2094 patients were included. Cases had higher rates of GERD. Univariate analysis demonstrated a positive association between GERD and laryngeal neoplasia (odds ratio, 1.33; 95% CI, 1.07-1.64). Multivariate analysis controlling for alcohol use history also demonstrated a positive association between GERD and laryngeal neoplasia (adjusted odds ratio, 1.29; 95% CI, 1.04-1.59). These results suggest increased odds of laryngeal carcinoma and carcinoma in situ in patients with GERD when controlling for smoking and drinking history.
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| http://dx.doi.org/10.1177/0194599820917669 | DOI Listing |
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