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http://dx.doi.org/10.1177/2047487320918365 | DOI Listing |
Cardiovasc Toxicol
October 2024
Department of Clinical Sciences, Division of Cardiovascular Medicine, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden.
The advent of heated tobacco products (HTPs) has introduced new variables in the study of nicotine delivery systems and their health implications. Amidst concerns over cardiovascular effects, this study aims to elucidate the acute impact of HTP inhalation on extracellular vesicles (EV) levels in young, healthy individuals. In this controlled, acute exposure study, 23 young, healthy volunteers were subjected to HTP inhalation.
View Article and Find Full Text PDFTob Use Insights
September 2024
Medical Clinic III, Lübeck, University Hospital Schleswig-Holstein, Lübeck, Germany.
Introduction: E-cigarettes and heated tobacco products (HTPs) are gaining worldwide significance. The tobacco industry is promoting these products as healthier alternatives to conventional cigarettes.
Methods: In this four-arm crossover study, we examined the acute effects of cigarette smoking, vaping IQOS, or vaping e-cigarettes (with or without nicotine) on hemodynamics, arterial stiffness, and small airways.
Toxics
February 2024
Univ. Lille, CHU Lille, Institut Pasteur de Lille, ULR 4483, IMPECS-IMPact de l'Environnement Chimique sur la Santé Humaine, F-59000 Lille, France.
Smoking is an established risk factor for various pathologies including lung cancer. Electronic cigarettes (e-cigs) and heated tobacco products (HTPs) have appeared on the market in recent years, but their safety or, conversely, their toxicity has not yet been demonstrated. This study aimed to compare the metabolome of human lung epithelial cells exposed to emissions of e-cigs, HTPs, or 3R4F cigarettes in order to highlight potential early markers of toxicity.
View Article and Find Full Text PDFNicotine Tob Res
July 2024
Department of Physical Analysis and Therapeutic Sciences, Graduate school of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Introduction: Oxidative state, a risk factor for several diseases, is increased by habitual conventional cigarette (CC) smoking. Reports have demonstrated that heat-not-burn cigarettes (HNBCs), which have recently become popular among smokers, generate less oxidative state than CC in smokers with a long smoking history. However, no previous study has examined oxidative state in young HNBC users.
View Article and Find Full Text PDFToxics
October 2023
Univ. Lille, CHU Lille, Institut Pasteur de Lille, ULR 4483, IMPECS-IMPact de l'Environnement Chimique sur la Santé, F-59000 Lille, France.
Electronic cigarettes (e-cig) and heated tobacco products (HTP) are often used as smoking cessation aids, while the harm reduction effects of these alternatives to cigarettes are still the subject of controversial debate, in particular regarding their carcinogenic potential. The objective of this study is to compare the effects of e-cig, HTP and conventional cigarette emissions on the generation of oxidative stress and genetic and epigenetic lesions in human bronchial epithelial BEAS-2B cells. Our results show that HTP were less cytotoxic than conventional cigarettes while e-cig were not substantially cytotoxic in BEAS-2B cells.
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