Two novel polycyclic polyprenylated acylphloroglucinols (PPAPs), garcibractinones A () and B (), as well as three known analogues doitunggarcinones A-B (-) and garcibracteatone () were isolated from fruits. Their structures were elucidated by comprehensive spectroscopic methods and single crystal X-ray diffraction. Compounds and possess an unprecedented caged tricyclo-[4.4.1.1] dodecane skeleton, and their biosynthetic pathways are also proposed. Compounds - were tested for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages.
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