Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials.

Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide (-GO) as a filler. -GO was first obtained by the strong oxidation and exfoliation of graphite. The structural, morphological and mechanical properties of the composites (CMCx/-GO) were evaluated, and the obtained composites were homogenous, transparent and brownish in color. The results confirmed that -GO may be homogeneously dispersed in CMC. It was found that the composite has an inhibitory activity against the Gram-positive , but not against Gram-negative . At the same time, it does not exhibit any cytotoxic effect on normal fibroblasts.