Antifungal drug screening: thinking outside the box to identify novel antifungal scaffolds.

Curr Opin Microbiol

Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States. Electronic address:

Published: October 2020

Invasive fungal infections are responsible for a significant disease burden worldwide. Drugs to treat these infections are limited to only four unique classes, and despite these available treatments, mortality rates remain unacceptably high. In this review, we will discuss antifungal drug screening and how the approach to identifying novel compounds needs move away from traditional growth-based assays in order to meet the demand for new drugs. We highlight specific examples of creative screening strategies that increase the likelihood of identifying compounds with desired activities and provide perspective to inspire development of novel screens for the identification of first-in-class antifungals.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652037PMC
http://dx.doi.org/10.1016/j.mib.2020.03.005DOI Listing

Publication Analysis

Top Keywords

antifungal drug
8
drug screening
8
screening thinking
4
thinking box
4
box identify
4
identify novel
4
novel antifungal
4
antifungal scaffolds
4
scaffolds invasive
4
invasive fungal
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!